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Last updated on 2025-11-18

2025-11-18

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Do you know Holland and Barrett Keto Gummies? They promise to help you enter ketosis and burn fats for fuel. But do they work? This article focuses on taking a closer look at Holland and Barrett Keto Gummies as well as finding out if it can be used to lose weight.

How Do Holland and Barrett Keto Gummies Work?

The purpose of these gummies is to get your body into a state of ketosis. Ketosis is basically the natural metabolic condition where your body burns fat instead of carbohydrates for energy. Hence, by reducing your carb intake while increasing fat consumption, you can induce ketosis in your body. The ingredients in these gums are meant to aid this process thus making it possible to reach and maintain ketosis.

Holland and Barrett’s keto gummies usually have constituents like exogenous ketones, MCT oil, collagen etc… These elements are known to boost the levels of ketone bodies present in your blood which serves as an alternate source of energy in your system. Moreover, the addition of collagen is said to assist healthy hair, skin, nails and joints during ketogenic dieting.

When you eat Holland and Barratt’s keto gummies, the exogenous ketones contained within them may help get you into a state of nutritional ketosis. This could be especially useful if one is new to the ketogenic diet or requires some support when starting off with it; moreover, MCT oil found inside them provides quick energy supply which assists patients who experience ‘keto flu’ upon starting on their low-carb high-fat routine.

Do Holland and Barrett Keto Gummies Help with Ketosis?

While these supplements might encourage ketosis in people’s bodies but remember that there’s no magic pill for losing weight. To achieve this goal therefore necessitates combination such as; eating less carbs but more fats diets (low carbohydrate high fat diet), regular exercises while being consistent. For instance, those gels should be seen as an aid to your ketogenic lifestyle and not as a sole way of achieving weight loss.

For some users, the benefits of consuming Holland and Barrett’s keto gummies include higher energy levels, improved mental clarity and less cravings. Despite this, results will vary from person to person and it is important that you pay attention to what your body says in order to make changes where necessary. Therefore, it is always advisable to consult with a healthcare provider before taking any new supplement especially if you have underlying health problems or are on other medications.

Therefore, Holland and Barrett Keto Gummies can help support your keto lifestyle easily and with great taste. These gummies along with precisely planned diet regimen will lead to ketosis as well as maintain it. Yet they are no magic wand for losing extra pounds but rather part of overall weight loss approach . Like any supplement, they should also be used alongside healthy living.

FAQs About Holland and Barrett Keto Gummies

1. Does Holland and Barrett Keto Gummies Have Any Side Effects?

As with any supplement, some people may have side effects when taking Holland and Barrett Keto Gummies. These include digestive issues such as diarrhea or stomach ache. You should always start out on a low dosage and see how your body reacts before increasing the intake.

2. Do you think I can eat Holland and Barrett Keto Gummies if my diet is limited in certain ways?

Holland and Barrett Keto Gummies are normally free from gluten and are suitable for those on keto or other low-carb diets. Nonetheless, it is important to examine what substances are listed in the ingredients that might cause allergic reactions or do not conform to dietary allowances.

3. How do I make Holland and Barrett Keto Gummies part of my daily routine?

When it comes to Holland and Barrett Keto Gummies, it would be best if you could follow the directions provided by the manufacturer as indicated on its label. Most of them will have a specific number of gummies for daily consumption that can either be taken with food or without food at all times. The most outstanding results will only come about when one keeps hydrated while consuming these gummies alongside an all-round ketogenic diet which is well-balanced.

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What about trying ketogenic diet to help in weight loss? Among the terms you may encounter is “keto supplements.” One such product is ViaKeto which has become popular over the years. Available at Chemist Warehouse, ViaKeto presents an easy way to enhance your ketogenic lifestyle. In this article, we will give a comprehensive guide on ViaKeto and how it can assist you in being healthier.

What is ViaKeto?

ViaKeto is a ketosis support supplement that contains a blend of natural ingredients designed to help you achieve ketosis faster and more efficiently. Ketosis is the metabolic state where instead of carbohydrates your body burns fat for fuel leading to weight loss and improvement in energy levels. Taking ViaKeto will enable your body to easily adjust into a low-carb, high-fat diet maximizing the benefits of following keto way of life.

ViaKeto has beta-hydroxybutyrate (BHB) as one of its key components which are types of ketones produced by the body while undergoing ketosis. By adding BHB (Beta-Hydroxybutyrate) into your system, you can increase blood ketone levels hence getting into ketosis and stay there longer. Apart from having BHB, other natural ingredients like MCT oil or green tea extract are also found in ViaKeto that can be used as added boosters for anyone going through keto journey.

How Does ViaKet Work?

Once ingested, these BHB and other contents get absorbed quickly into your bloodstream after consuming ViaKetosupplementations. These ketones then act as alternative sources of energy for your body thereby speeding up the process of entering into ketosis. As metabolism switches from using carbohydrates to burning fats for energy purposes, you might experience mental clarity weight loss and increased energy levels.

Also people who adopt ketogenic diets often have what they refer to as “keto flu” when starting out. This can manifest in fatigue, headaches, muscle cramps as the body adjusts to using new source of fuel. By taking ViaKeto you may be able to decrease these symptoms and make transitioning into ketosis easier for your body.

How to Incorporate ViaKeto into Your Routine

For best results, it is recommended to take ViaKeto as part of a ketogenic diet. This means eating a diet high in healthy fats, moderate in proteins and low in carbohydrates. A ketogenic diet combined with regular use of ViaKeto will enable you maximize benefits of ketosis and help weight loss.

However, keep in mind that although ViaKeto can help maintain your ketogenic lifestyle it cannot replace a balanced diet and exercise routine. Resulting from this, it is crucial for you to eat well balanced foods, keep drinking water and exercise regularly. When these behaviors are combined with consuming ViaKeto however one’s weight loss journey becomes more efficient.

Is ViaKet Safe?

Thus, it is always a wise decision to seek advice from a healthcare professional before trying out any new additions such as these, especially when you have underlying health conditions and are under medication. Although it is safe for most people, individual effects may vary. You should therefore be careful and consult a health practitioner if you feel that the supplement has got any side effects on your body.

ViaKeto is a ketosis support supplement available at Chemist Warehouse that can help you achieve your weight loss goals on a ketogenic diet. Also, by incorporating ViaKeto into your daily routine along with nutritious eating and regular exercise, you can assist the body in the process of moving into ketosis and maximize the benefits of living a keto lifestyle. If you are thinking about using ViaKeto, it would be better to consult with professionals from medical institutions just to make sure whether this choice will meet your needs or not.

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Are you looking to supplement your keto diet with a tasty treat? Look no further than The Apple Keto Gummies! These delicious gummies are packed with all the benefits of a keto-friendly snack, without the guilt of added sugars. In this comprehensive review, we will explore the numerous benefits of The Apple Keto Gummies and why they should be your go-to snack while following a ketogenic lifestyle.

Benefits of The Apple Keto Gummies

1. Increased Energy Levels

One of the key benefits of The Apple Keto Gummies is their ability to provide a sustained source of energy throughout the day. With their low carbohydrate content and high fat content, these gummies are the perfect snack to keep you feeling energized and focused, without the crash that comes with sugary snacks.

Additionally, the medium-chain triglycerides (MCTs) found in these gummies can quickly be converted into ketones, which are used by the body as a primary source of fuel. This can lead to increased mental clarity and improved cognitive function, making The Apple Keto Gummies a must-have for anyone following a keto diet.

2. Appetite Control

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Another benefit of The Apple Keto Gummies is their ability to help control appetite and cravings. The combination of healthy fats and protein in these gummies can help you feel full and satisfied for longer periods, reducing the temptation to reach for unhealthy snacks.

Additionally, the fiber content in these gummies can help regulate blood sugar levels and prevent spikes in insulin, which can lead to cravings for sugary foods. By incorporating The Apple Keto Gummies into your daily routine, you can better manage your hunger and stay on track with your keto goals.

3. Weight Loss Support

Many people turn to the keto diet for its ability to promote weight loss, and The Apple Keto Gummies can be a valuable tool in achieving your weight loss goals. By providing a low-carb, high-fat snack option, these gummies can help you stay in ketosis and burn fat for fuel, leading to increased fat loss over time.

Additionally, the thermogenic effect of MCTs can boost your metabolism and increase the number of calories your body burns at rest. This can help you achieve a calorie deficit more easily, leading to faster and more sustainable weight loss results when combined with a healthy diet and regular exercise.

Why Choose The Apple Keto Gummies

1. Quality Ingredients

The Apple Keto Gummies are made with high-quality, keto-friendly ingredients that are free from added sugars, artificial flavors, and preservatives. Each gummy is carefully crafted to provide a delicious and nutritious snack that supports your keto lifestyle without compromising on taste or quality.

With ingredients like grass-fed collagen, MCT oil, and natural apple flavor, you can feel confident knowing that The Apple Keto Gummies are a wholesome and delicious choice for your snacking needs.

2. Convenience and Portability

Whether you’re on the go or looking for a quick and easy snack at home, The Apple Keto Gummies are the perfect option for busy individuals following a keto diet. These gummies come in a convenient grab-and-go pack that can easily be stashed in your bag or desk drawer for a quick energy boost whenever you need it.

Additionally, the portable nature of these gummies makes them a great option for travel or on-the-go snacking, ensuring that you always have a keto-friendly snack on hand to keep you feeling satisfied and energized throughout the day.

3. Delicious Taste and Variety

While following a keto diet can sometimes feel restrictive when it comes to snack options, The Apple Keto Gummies offer a delicious and satisfying treat that you can enjoy guilt-free. With their natural apple flavor and chewy texture, these gummies are sure to satisfy your sweet tooth and curb your cravings for sugary snacks.

Additionally, The Apple Keto Gummies come in a variety of pack sizes, allowing you to choose the option that best suits your snacking needs. Whether you prefer a single serving pack for on-the-go convenience, or a larger pack for stocking up at home, these gummies offer versatility and flexibility to fit your lifestyle.

Final Thoughts on The Apple Keto Gummies

Overall, The Apple Keto Gummies are a delicious and convenient snack option that can provide numerous benefits for individuals following a keto diet. From increased energy levels and appetite control to weight loss support and quality ingredients, these gummies are a valuable addition to any keto lifestyle.

Whether you’re looking for a quick and easy snack to keep you going throughout the day, or a satisfying treat to curb your cravings, The Apple Keto Gummies offer a delicious and nutritious solution that you can feel good about. With their quality ingredients, convenient packaging, and delicious taste, these gummies are sure to become a staple in your keto snack rotation.

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The ketogenic diet has become increasingly popular for its ability to help individuals lose weight, improve their health, and boost their energy levels. However, following a strict keto diet can be challenging, especially when it comes to finding tasty snacks that fit within the guidelines of the diet. That’s where Keto Tone Sugar Free Gummies come in – a delicious and healthier alternative for keto dieters looking to satisfy their sweet tooth without straying from their diet.

The Benefits of Keto Tone Sugar Free Gummies

Keto Tone Sugar Free Gummies are a great option for those following a ketogenic diet because they are low in carbs and sugar-free. This makes them a perfect snack for anyone looking to maintain ketosis while still satisfying their cravings for something sweet. These gummies are made with natural ingredients and are free from artificial flavors and colors, making them a healthier choice compared to traditional gummy candies.

One of the key benefits of Keto Tone Sugar Free Gummies is that they are formulated to help support your body’s ketosis process. The gummies are packed with BHB (beta-hydroxybutyrate) ketones, which can help your body burn fat for fuel more efficiently. This can help you stay in ketosis longer and experience greater weight loss results.

Additionally, Keto Tone Sugar Free Gummies are a convenient and portable snack option for keto dieters on the go. Whether you’re traveling, at work, or just need a quick pick-me-up between meals, these gummies are easy to take with you wherever you are. They are also a great option for satisfying your cravings without derailing your progress on the keto diet.

How to Incorporate Keto Tone Sugar Free Gummies into Your Keto Diet

There are many ways to enjoy Keto Tone Sugar Free Gummies while following a ketogenic diet. You can snack on them on their own for a quick and easy treat, or you can incorporate them into recipes to add a burst of flavor and sweetness. For example, you can chop up the gummies and mix them into your favorite keto-friendly yogurt or use them as a topping for a sugar-free cheesecake.

Another way to enjoy Keto Tone Sugar Free Gummies is to use them as a post-workout snack to help replenish your energy levels and support muscle recovery. The BHB ketones in the gummies can help your body recover faster after exercise and keep you on track with your fitness goals. Plus, the delicious fruity flavors of the gummies make them a tasty reward for a hard workout.

For those looking to satisfy their sweet tooth without breaking their diet, Keto Tone Sugar Free Gummies are a delicious and guilt-free option. With a variety of flavors to choose from, including strawberry, cherry, and orange, there is a gummy for every taste preference. Whether you’re craving something sour, sweet, or tangy, these gummies have you covered.

Frequently Asked Questions about Keto Tone Sugar Free Gummies

Q: Are Keto Tone Sugar Free Gummies safe for diabetics?

A: Yes, Keto Tone Sugar Free Gummies are safe for diabetics because they are sugar-free and low in carbs. However, it’s always best to consult with your healthcare provider before adding any new snacks to your diet.

Q: How many gummies can I eat on a ketogenic diet?

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A: It’s best to follow the serving size recommendations on the packaging of Keto Tone Sugar Free Gummies. Typically, one serving is around 2-4 gummies, but this may vary depending on your individual nutritional needs.

Q: Can I eat Keto Tone Sugar Free Gummies if I’m not on a keto diet?

A: Yes, anyone can enjoy Keto Tone Sugar Free Gummies as a low-sugar, healthier snack option. However, they are specifically formulated to support ketosis and may be most beneficial for individuals following a ketogenic diet.

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With the rising popularity of the ketogenic diet and the increasing use of apple cider vinegar (ACV) as a health supplement, the combination of ACV and keto has become a hot topic in the health and wellness community. Both ACV and the ketogenic diet have been praised for their potential health benefits, including weight loss, improved digestion, and increased energy levels. When used together, these two supplements may offer even greater benefits. In this article, we will take a deep dive into the combined benefits of ACV and keto, exploring how they work together to support overall health and well-being.

The Science Behind ACV and Keto

Apple cider vinegar is made from fermented apples and contains acetic acid, which has been shown to help regulate blood sugar levels, improve digestion, and support weight loss. The ketogenic diet, on the other hand, is a high-fat, low-carb diet that forces the body to burn fat for fuel instead of carbohydrates. When combined, ACV and keto may work synergistically to enhance fat burning, promote satiety, and support overall metabolic health.

When you consume ACV while following a ketogenic diet, the acetic acid in ACV may help your body enter a state of ketosis more quickly. Ketosis is a metabolic state in which the body burns fat for fuel instead of glucose, leading to greater fat loss and increased energy levels. By adding ACV to your keto regimen, you may be able to amplify the benefits of both supplements and accelerate your progress towards your health goals.

Additionally, ACV has been shown to improve insulin sensitivity, which is important for those following a ketogenic diet. Insulin resistance can hinder the body’s ability to enter ketosis and burn fat efficiently. By incorporating ACV into your keto routine, you may be able to improve insulin sensitivity and optimize your body’s ability to utilize fat for energy.

Benefits of Combining ACV and Keto

1. Enhanced Weight Loss: ACV and keto are both known for their ability to promote weight loss. When used together, they may create a powerful combination that accelerates fat burning and helps you reach your weight loss goals more quickly.

2. Improved Digestion: ACV has been shown to support digestive health by promoting the growth of beneficial bacteria in the gut. When paired with the high-fat, low-carb nature of the ketogenic diet, ACV may help alleviate digestive issues such as bloating and constipation.

3. Increased Energy Levels: Many people report feeling increased energy and mental clarity when following a ketogenic diet. By adding ACV to your routine, you may experience a further boost in energy levels due to its ability to stabilize blood sugar levels and enhance fat burning.

Tips for Incorporating ACV and Keto into Your Routine

1. Start Slow: If you’re new to either ACV or the ketogenic diet, it’s important to start slow and gradually increase your intake. Too much ACV or too few carbohydrates can lead to digestive issues or low energy levels.

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2. Stay Hydrated: Both ACV and keto can have diuretic effects, so it’s important to drink plenty of water throughout the day to stay hydrated and support your overall health.

3. Monitor Your Progress: Keep track of how you’re feeling and any changes in your weight, energy levels, or digestion. Adjust your ACV and keto intake as needed to optimize your results.

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Actress/author Rebel Wilson got her big break as “Fat Amy” in the film “Pitch Perfect” – from that moment on, her body and being a self-described “proud fat female” became a huge part of her public persona. So much so that when she decided to lose weight for her health, her now former agent said her “career would be over” if she did. In Rebel’s first-ever sit-down with Oprah, as part of the “Making the Shift” special, the pair discusses the complexities behind Rebel’s decision to lose weight, her new book “Rebel Rising,” the “emotional war” she had to fight within herself, and how she’s doing now - a few years later. “Making the Shift,” which aired on May 9 to a live studio audience, unpacks the multifaceted, preconceived notions we have about weight, from the profound impact diet culture has had on our society to how we can reframe harmful narratives surrounding our weight and our bodies. The conversation – featuring Rebel Wilson, Busy Philipps, Amber Riley, and many others – brought together individuals, communities and medical experts to bridge the science of “weight” with a new outlook that brings the health and wellbeing of our bodies into focus. Disclaimer: This content is for informational purposes only and does not constitute medical advice, diagnosis or treatment. It should not be regarded as a substitute for guidance from your healthcare provider. To learn more about WeightWatchers, go to weightwatchers.com ►►Still haven’t subscribed to WW on YouTube? https://www.youtube.com/user/weightwatchers?sub_confirmation=1 FOLLOW WeightWatchers: Instagram: https://www.instagram.com/weightwatchers/ Facebook: https://www.facebook.com/weightwatchers TikTok: https://www.tiktok.com/@weightwatchers #oprah #rebelwilson #makingtheshift #weightwatchers

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- 💌 **Join My Exclusive Community for Free** for Expert Health Insights: https://www.medicalwisdom.org/ -- Losing weight without trying? 📉 Unintentional weight loss can be a warning sign for underlying health issues. 💡 Dr. Omar explains the top causes, and discover how factors like diabetes, gastrointestinal issues, and even loneliness contribute to unexpected weight changes. 🤔 Learn how to recognize the symptoms and take action for better health! 💡 Watch now to understand the causes and symptoms! Like and subscribe if you want to see more content like this. Share your questions or experiences in the comments below! 🔔 Stay informed and take control of your health! --- ✨ Welcome to **Medical Wisdom with Dr. Omar, M.D., Ph.D.** ✨ – your trusted source for health insights and medical knowledge. Join our community of health-conscious individuals and gain exclusive access to a wealth of information that empowers your health and wellness journey. 🔔🔔 **Subscribe Now** for Health Insights: https://www.youtube.com/channel/UCeR7zEzoilZKhhtua8BYr_A?sub_confirmation=1 📩 **Got Questions or Topics You’re Curious About?** Let us know in the comments! Dr. Omar personally reads your feedback and loves to tailor content to your interests. 💡👇 👭📲 **Share the Knowledge** 💌💪 : Know someone who could benefit from this video? Spread the health by sharing it with someone you care about: ➡️ LINK 👀🎥 **Must-Watch Next**: Dive deeper into your health and wellness for more insights: https://www.youtube.com/@medicalwisdom/videos - 📘 Meta/Facebook: https://www.facebook.com/medicalwisdomwithdromar - 📸 Instagram: @medicalwisdomwithdromar https://www.instagram.com/medicalwisdomwithdromar - 🐦 X/Twitter: @medicalwisdom_ https://x.com/medicalwisdom_ 🚨 **Disclaimer**: This content is for educational and entertainment purposes only and in case a medical topic is discussed, the information presented is in no way medical advice; please consult with your healthcare provider for personalized medical advice; also, the views expressed here are Dr. Omar's alone, and do not represent any other organization or group to which he is affiliated. 🚨 🌟 **Why Subscribe?** 🌟 By subscribing to our channel, you’re not just joining a community; you’re gaining access to a wealth of knowledge that can make a real difference in your life. From breaking down complex medical topics into easy-to-understand videos to providing actionable health tips, Dr. Omar, M.D., Ph.D. a Harvard Medical School honors graduate with his unique expertise, is here to guide you through your health and wellness journey. Plus, you’ll be the first to know when we post new videos and updates! #unintentionalweightloss #healthylifestyle #weightlossconcerns #medicaleducation #drOmar #cancersymptoms #mentalhealthawareness #thyroidissues #gastrohealth #diabetessymptoms #eatingdisorders #socialisolation #depressionawareness #doctoradvice #healthtips #preventivehealth #stayhealthy #loneliness

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This is an excerpt of the keynote 'Current Status and Potential Future of Obesity Therapies' by Associate Vice President James Trevaskis (Eli Lilly) at the conference Metabolism Day 2025. He provides an insightful overview of the current obesity therapeutics landscape and future innovations beyond GLP-1 receptor agonists, discusses the evolution of obesity treatments, highlights the success of GLP-1s like semaglutide and tirzepatide, while exploring emerging therapies including: Retatrutide - Eli Lilly's tri-agonist (GIP/GLP-1/glucagon) showing up to 24% weight loss Small molecule GLP-1 agonists - Oral alternatives like orforglipron Amylin-based therapies - The next major non-incretin class for obesity treatment Combination approaches - Including activin receptor inhibitors to preserve lean muscle mass during weight loss Trevaskis addresses key challenges in obesity drug development, including patient response variability, body composition changes, and the need for novel biological targets. He also shares Eli Lilly's innovative CRISPR-based approach for rapid target validation in obesity research. This talk offers valuable insights into the future of obesity medicine, discussing both the promise and challenges of developing more effective, personalized treatments for metabolic disease.

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Anna and Samantha Martin’s Keto Gummies have taken the health and wellness industry by storm, thanks to their appearance on the popular TV show Shark Tank. The two sisters developed their gummy supplement as a way to help others achieve their weight loss and wellness goals, and their product has quickly become a favorite among consumers looking for a natural and effective solution. In this article, we will explore the story behind Anna and Samantha Martin’s Keto Gummies, their journey to success on Shark Tank, and the positive impact their product has had on the lives of many.

The Journey to Shark Tank Success

Anna and Samantha Martin’s journey to success on Shark Tank was not an easy one. The two sisters spent years researching and perfecting their formula for Keto Gummies, working tirelessly to create a product that would truly make a difference in the lives of their customers. When they finally got the opportunity to pitch their product on the show, they were nervous but confident in the quality of what they had created.

On the Shark Tank stage, Anna and Samantha Martin’s Keto Gummies quickly caught the attention of the investors. The sisters shared their personal story and the science behind their product, leaving the investors impressed with their dedication and knowledge. In the end, they were able to secure a deal that would help them take their business to the next level and reach even more people in need of a natural and effective weight loss solution.

The Impact of Keto Gummies

The success of Anna and Samantha Martin’s Keto Gummies can be attributed to the quality and effectiveness of their product. Made with all-natural ingredients and free of any harmful additives, these gummies have helped countless individuals achieve their weight loss goals and improve their overall health and wellness. Customers have raved about the positive effects of Keto Gummies, reporting increased energy levels, improved focus, and a reduction in cravings for unhealthy foods.

What sets Keto Gummies apart from other weight loss supplements is their focus on sustainability and long-term health. Anna and Samantha Martin understand that true wellness is about more than just losing weight; it’s about feeling good in your body and making healthy choices that support your overall well-being. That’s why they have created a product that not only helps people shed pounds but also promotes a balanced and sustainable approach to weight management.

Frequently Asked Questions

Q: How do Keto Gummies work?

A: Keto Gummies work by supporting the body’s natural fat-burning processes. By providing a dose of exogenous ketones, these gummies help stimulate ketosis, a state in which the body burns fat for fuel instead of carbohydrates. This can lead to increased fat loss, improved energy levels, and better mental clarity.

Q: Are Keto Gummies safe to use?

A: Yes, Keto Gummies are made with all-natural ingredients and are free of any harmful additives or chemicals. They have been extensively tested for safety and efficacy, and have been proven to be a safe and effective weight loss supplement for most individuals.

Q: How long does it take to see results with Keto Gummies?

A: The results of Keto Gummies can vary from person to person, but many customers report seeing positive changes within the first few weeks of use. For best results, it is recommended to take Keto Gummies consistently as part of a healthy diet and exercise routine.

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Burn Fat, Keep Muscle! Here’s How: 💪 Want to burn fat without sacrificing your hard-earned muscle? Balance is the key! 🍗 Protein is your ally—aim for 2.2g per kg of body weight to fuel muscle repair and growth. 🏋️‍♂️ Strength train 3-4 times a week to preserve muscle while in a calorie deficit. 🚴‍♀️ Keep cardio in check—opt for short HIIT sessions or just 1-2 steady-state sessions weekly. ⚖️ Don’t cut calories too hard—a 300-500 calorie deficit is enough to burn fat without losing muscle. ✨ Slow and steady progress = lasting results! 👉 Follow for more tips to crush your fitness goals the right way! 💥 #foundationalexercises #strengthtraining #musclebuilding #fitnesstips #workoutmotivation #gymlife #fitfam #onlinecoach

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Dr David Johnson highlights new preoperative recommendations to protect against consequences of some diabetes and weight loss drugs that delay gastric emptying. https://www.medscape.com/viewarticle/994762?src=soc_yt -- TRANSCRIPT --- Hello. I'm Dr David Johnson, professor of medicine and chief of gastroenterology in Eastern Virginia Medical School in Norfolk, Virginia. Recent national media attention has focused on the gastrointestinal (GI) side effects of glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs are used to treat type 2 diabetes and weight loss. The GI side effects include nausea, vomiting, and gastroparesis-like symptoms. I wanted to emphasize two key points especially important to clinicians providing this class of therapy. One: Clinicians need to be increasingly aware of the potential GI side effects and inform their patients when they start to prescribe these medications. And two: The American Society of Anesthesiologists (ASA) has recently released consensus-based recommendations for preoperative assessment and management of adults and children undergoing surgery who are taking these medications. The recommendations also apply to endoscopic procedures whereby anesthesia will be delivered. Gastric Impact of GLP-1 Agonists What are these GLP-1 agonists? The drugs for weight loss include liraglutide (Saxenda and Victoza) and semaglutide (Ozempic, Wegovy, Rybelsus, among others). The type 2 diabetes medications include semaglutide, dulaglutide (Trulicity), and exenatide (Byetta, Bydureon BCise), among others. They can be taken daily or by injection once a week. The GLP-1 agonist drug class works at the GI level to increase insulin secretion and decrease glucagon release, both of which mediate glycemic control, particularly postprandially. The drugs slow the gastric motility through decreased peristalsis and increased tonic contractility of the pylorus, essentially causing a delay in gastric emptying. Dr Michael Camilleri and his colleagues at the Mayo Clinic, in Rochester, Minnesota, conducted a small randomized, placebo-controlled double-blind study of the GLP-1 agonist liraglutide to investigate the mechanism of weight loss in patients who were overweight. They showed that there was a diminution in gastric emptying over 16 weeks in patients taking liraglutide. They found evidence of tachyphylaxis, but the rate of gastric emptying of solids remained slow compared with placebo, even at 16 weeks. Despite the observed waning of the gastric impact, we just don't know how long significant side effects persist when patients stop the drug for good. There are some reports of patients with protracted symptoms a year or more after they've stopped their GLP-1 agonist medications. Guidance for Preoperative Management These drugs would commonly be reviewed before patients go through procedures, and we need to be better aware as we start to see these patients for endoscopy. The ASA recommendations address the potential consequences of delayed gastric emptying and provide guidance for preoperative management of these drugs to prevent regurgitation and pulmonary aspiration of gastric contents. In patients on daily dosing, the ASA recommends holding these agents the day prior to the procedure. For patients on weekly dosing, the recommendations suggest withholding the dose a week before the procedure. Importantly, this should be in consultation with their diabetologist, just to assess any need for a bridging therapy to avoid hypoglycemia. On the day of the procedure, if GI symptoms, such as severe nausea, vomiting, retching, abdominal pain, and bloating, are present, clinicians should consider delaying the elective procedure and discuss the risks of the potential risks for aspiration. If the patient has no symptoms and the GLP-1 agonist has been withheld as advised, then you should proceed as usual. But if the patient has no symptoms and has not held their GLP-1 agonist, you should proceed with what the anesthesiologists call the "full stomach" precaution, which considers patients at potentially high risk for aspiration. There's a way of checking for that. Some centers can do a quick ultrasound on the stomach and see if there's food, debris, or liquid, and if that is not the case, they could proceed with no delay. But if there is no way to check gastric contents, then you should manage accordingly, which may require intubation or postponing an elective procedure for another day. These are new and changing issues. In our world as gastroenterologists, we should be considering — very strongly — mitigating strategies to protect the patients on this wonderful class of therapy. Sometimes these drugs can have significant side effects that we need to at least be aware of. Nothing is perfect, but let us be better informed. https://www.medscape.com/viewarticle/994762?src=soc_yt

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