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Summary: Can Ozempic-like drugs help treat Parkinson’s disease? A new study says no—at least not yet. In this episode, we unpack the results of a major clinical trial that tested exenatide, a GLP-1 drug, in nearly 200 people with Parkinson’s. While earlier research raised hopes, this study found no improvement in symptoms or disease progression. We explore what this means for future treatment strategies, why understanding brain mechanisms is key, and whether other GLP-1 drugs still hold promise. This conversation brings clarity to a complex and evolving area of science. Disclaimer: This podcast is intended for educational and informational purposes only. It does not substitute for professional medical advice, diagnosis, or treatment. Always speak to your healthcare provider before starting or stopping any medications, especially if you have a neurological condition such as Parkinson’s disease. Scientific References & Further Reading: The Lancet. (2024). Exenatide once weekly for 96 weeks in early Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Parkinson’s Foundation. (2024). Can GLP-1 medications help Parkinson’s disease? Michael J. Fox Foundation. (2024). Exenatide and GLP-1 drug class show mixed results in Parkinson’s research. University of Alabama at Birmingham. Expert commentaries on exenatide and neuroprotection. Nature Reviews Neurology. (2023). Incretin-based therapies in neurodegenerative diseases: Promises and pitfalls.

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