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Thirteen years after her gastric bypass, Nikki encountered a family problem that resulted in her gaining 70 pounds back. So she decided to try GLP-1 medications. She shares her results in Episode 31 of The Pound of Cure Weight Loss Podcast. https://mtr.bio/pocpodcast #health #weightloss #weightlosssurgery #gastricbypass #gastricsleeve #obesity #apoundofcure #drweiner #nutrition #nutritionprogram #GLP1Medications #GLP1 #bariatricsurgery #loseweight #weightlossmedications #gastricsurgery

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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].

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❤❤For my weight loss services or program, Email :- [email protected] ❤❤To Buy These Products From Amazon :- https://www.amazon.in/shop/dr.shikhasingh Subscribe to Dr.Shikha Singh youtube.com/c/DrShikhaSingh Follow me on Instagram instagram.com/dr_shikhasingh/ My Weight Loss Meal/Diet Plans:- ------------------------------ Weight Loss Egg Recipes In Hindi | Egg Recipes For Fast Weight Loss In Hindi|How To Lose Weight Fast :- https://youtu.be/o_WDr77iNI4 Weight Loss Rice In Hindi | Brown Rice For Weight Loss | Brown Rice Recipe In Hindi| Lose 10 Kg Fast :- https://youtu.be/OVUl0NxWfOo Aloe Vera Juice For Weight Loss In Hindi | How To Lose Weight Fast In Hindi | Aloe Vera Juice Recipe :- https://youtu.be/0Vfb20tcpUQ Easy Diet Plan For Weight Loss In Hindi | Indian Diet Plan In Hindi|How To Lose Weight Fast In Hindi :- https://youtu.be/1f6krXeS54I Weight Loss Thandai Recipe(In Hindi)| Thandai Recipe(In Hindi|Thandai Powder|How To Lose Weight Fast :- https://youtu.be/RuRxg5yoxKM Weight Loss Chia Pudding(In Hindi) | How To Lose Weight Fast(In Hindi)|Weight Loss Recipes(In Hindi) :- https://youtu.be/2XxROYkpxBs 5 Weight Loss Sandwich Recipes In Hindi|Weight Loss Recipe In Hindi|Healthy Breakfast Ideas In Hindi :- https://youtu.be/1snoCULpQ0I Weight Loss Chutney (In Hindi) | How To Lose Weight Fast (In Hindi) :- https://youtu.be/-wUsPxRGhVY Weight Loss Bread(In Hindi) | Whole Wheat Bread(In Hindi) | Brown Bread | Atta Bread |No Maida Bread :- https://youtu.be/qSr85sw-lD8 PCOS Drink For Weight Loss(In Hindi) | How To Lose Weight Fast(In Hindi)-No Exercise/No Strict Diet :- https://youtu.be/MW5Te6Q9x8c Quick Weight Loss With Flax Seeds(In Hindi)| 5 Flax Seed Recipes| Instant Belly Fat Burner :- https://youtu.be/Jtosex_KkSc Diet Plan To Lose Weight Fast In Hindi | Lose 10 Kgs In 10 Days :- https://youtu.be/9et2fmdJ3jA How To Get Flat Belly In 5 Days | Get Flat Stomach Without Diet-Exercise | Instant Belly Fat Burner :- https://youtu.be/cQCHs3xbSnE Almond Milk For Quick Weight Loss In Hindi-How To Make Almond Milk At Home In 1 Min- Health Benefits :- https://youtu.be/tS8_T_-lkTo Get Flat Belly/Stomach in 7 Days - No Diet/No Exercise - 100% Natural Star Anise Detox Diet Drink :- https://youtu.be/dJnruMVG7sA PCOS Diet For Weight Loss| Pcos Summer Diet Plan| PCOD Diet Chart| Lose Weight Fast 10Kgs In 10 Days :- https://youtu.be/yFY4ojEC2Z8 Healthy Dessert For Weight Loss/Basil Kheer Recipe https://youtu.be/jPkbn4Kky6Q Turmeric Tea Recipe :- https://youtu.be/5iXRZPx7Yx4 Weight Loss Breakfast / Quinoa Pulao Recipe:- https://youtu.be/J-2XHgm8UWE Weight Loss Dinner Recipes:- https://youtu.be/I39UIz-RLDI Weight Loss Salad Recipes:- https://youtu.be/dPWOENkLoOM Summer Weight Loss Diet Plan:- https://youtu.be/MzU2WQ8aeQw Weight loss Lunch recipe:- https://youtu.be/9EdueaGW1Zg Weight Loss Breakfast Recipe:- https://youtu.be/VOdjlBKo0ZA Flat Belly Weight Loss Diet Soups:- https://youtu.be/Zn7hHhugAy4 Weight Loss Smoothies:- https://youtu.be/nQR7Q8nUz_E Flat Belly Drink:- https://youtu.be/x0zB7kl-VmQ Jeera Detox Drink:- https://youtu.be/8eeIyoOs18Y Weight Loss Roti Recipe:- https://youtu.be/WDjFmOnV9iU Cinnamon Detox Drink:- https://youtu.be/2dCcza-rwvc How I Lost 45Kgs Fast Diet Plan:- https://youtu.be/bFolXZdftNE My transformation Story/ How I Lost 45Kgs Fast:- https://youtu.be/5Dz0D2pC4pg This is a channel through which I share My journey and experiences of weight loss with my viewers. These remedies and diets worked on me but each person is different and react differently to these remedies and diets so please consult your doctor before trying any remedy and diets suggested in my video.The recommendations given on this channel may not work for everyone,and should not be considered as an excuse to not visit your doctor or consult a medical practitioner. Thanks for watching and don't forget to SUBSCRIBE,LIKE,SHARE,COMMENT.

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On World Obesity day, let us demystify myths around obesity! Five decades ago/ Pre 1980’s era, Obesity, type 2 diabetes & other metabolic diseases were a rare phenomenon. Our grandparents never had obesity- & they never had these fad recommendations of high protein, low carb & more but they had one aspect of our biology which we miss out now- balanced & diverse gut microbiome. No brainer- the foods they ate were rich in fibre & polyphenols which were food for their microbiome. Their gut microbes synthesised these food substrates & converted them into short chain fatty acids which secreted GLP-1- the hormone required to regulate our metabolism, satiety & appetite. GLP-1 communicates with Pancreas to regulate blood sugar response & communicates with the brain to modulate our hunger responses. Besides, our gut microbiome can make it hard to lose weight by 1.Low Grade Chronic Inflammation : Synthesising foods, not compatible with our biology, into pro-inflammatory metabolites such as LPS, TMAO & more which when released into the blood stream triggers inflammatory responses. In other words, this leads to high fat storage & low fat export. 2.Gut-Brain Axis: Gut communicates with the brain via Vagus nerve & impact hunger responses by impacting production of ghrelin, leptin & other hunger hormones. 3.If gut microbiome is less diverse, not producing enough enzymes or have now butyrate producing bacteria, it could stimulate hunger However, corporatization of foods & fad diets such as high protein & quantified nutrition has changed the entire microbial ecosystem inside our body triggering a wave of chronic inflammation. One of the most important reasons for obesity is degradation of GLP-1 which is caused by multiple metabolic pathways including those impacted by gut & oral microbiome. However, GLP-1 drugs being marketed as the solution for metabolic issues, leaves a lot of questions unanswered as it does not address the root cause- gut microbial dysbiosis. Besides, it brings its share of side effects & collateral damage including gastrointestinal issues- diarrhoea, bloating, constipation & more, loss of healthy muscle mass loss, inflammation of pancreas & even high risk of pancreatic cancer. Today's video discusses the role of gut & oral microbiome in obesity & each of the pathways associated with degradation of GLP-1 as well as what could make GLP-1 drugs ineffective & harmful Citations below https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112002/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082693/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187364/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266401/ https://pubmed.ncbi.nlm.nih.gov/23892476/ https://pubmed.ncbi.nlm.nih.gov/22506074/ https://www.nature.com/articles/s41598-018-20549-0

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