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Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #Longevity
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My personal review of a cannabis strain called Critical CBD. I didn't talk enough about the effects. Its a 'low' or 'body' high. Good for pain and numbing. Doesn't work well for nausea. Its smokes smooth and has a nice pine smell. It tastes fine when smoked. Over all 3.5?
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Fibromyalgia Testimonies and How Using Hempworx CBD Products Has Helped Fibromyalgia (FM) is a medical condition characterized by chronic widespread pain and a heightened pain response to pressure. Other symptoms include tiredness to a degree that normal activities are affected, sleep problems and troubles with memory. Some people also report restless legs syndrome, bowel or bladder problems, numbness and tingling and sensitivity to noise, lights or temperature. Fibromyalgia is frequently associated with depression, anxiety and post traumatic stress disorder. Other types of chronic pain are also frequently present. This video is about how Hempworx CBD Products have helped relief symptoms of Fibromyalgia from just a few people. There so many examples of this that we could not include them all in this video. If this video has been helpful please feel free to leave a like, share and subscribe to our channel. Feel free to contact the person that referred you to this video about Hempworx CBD. If you are interested in your own video visit http://www.abuelodesigns.com/ FDA Disclaimer These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. MyDailyChoice, Inc. assumes no responsibility for the improper use of and self-diagnosis and or treatment using these products. Our products should not be confused with prescription medicine and they should not be used as a substitute for medically supervised therapy. If you suspect you suffer from clinical deficiencies, consult a licensed qualified medical doctor. You must be at least 18 years old to visit our website and make product purchases. We do not make any health claims about our products at MyDailyChoice. Before taking our products, it’s wise to check with your physician or medical doctor. It s especially important for people who are: pregnant, chronically ill, elderly under 18, taking prescription or over the counter medicines. None of the information on our website is intended to be an enticement to purchase and may not be construed as medical advice or instruction. The use of any of our products for any reason, other than to increase general health & wellness,is neither, implied nor advocated by MyDailyChoice,
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Our Delta-10 oils are produced from hemp, legally and responsibly by PhD chemists, testing at over 95% with the rest being cannabinoid minors. Please Note: We use high quality Cartology cartridges with ceramic wick atomizers that absorb oil after filling. Although some cartridges may appear to be under-filled, it is really just the priming of the wick. Click here to view our lab test results FREQUENTLY ASKED QUESTIONS (FAQ) You might’ve heard of Delta 9, but Delta 10 THC is a little different. Delta 10 THC is a cannabinoid found in trace amounts of cannabis. Delta 10 can give you a euphoric sense of relief like Delta-9, but it is not nearly as strong. How is Delta 10 THC made? Delta-10 products are typically made in an extraction facility, distilled and mixed to make finished products. When it occurs naturally in hemp, it is a product of the natural degradation of delta-9 THC as opposed to a cannabinoid created by the plant itself. How Does Delta-10 THC Affect the Body? Little peer-reviewed scientific research has been conducted on how Delta 10 THC interacts with the body so far, but the anecdotal evidence is promising. What we do know is that the compound binds with CB1 receptors in the brain and central nervous system and some CB2 receptors via the body’s endocannabinoid system. WARNING! This products is not meant for ingestion. Vaporizing is hazardous to your health. Keep out of reach of children. Must be 21 years or older to purchase. This product has not been evaluated by the FDA or any other regulatory body for safety or efficacy. Do not use this product if you are pregnant, nursing, or planning to become pregnant. Use of this product can result in failing a drug test for Marijuana. Use of this product may induce intoxicating/ psychoactive effects which can be delayed up to 4 hours. Do not operate a vehicle or machinery after consuming this product. To determine this product’s effect, use less than one serving for the initial dose, as the effects of this product can range widely. A Hemp Product, contains less than 0.3% delta-9-THC & THCA combined. #delta10
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Con questo video non si intende incitare nessuno all'utilizzo o alla produzione di sostanze stupefacenti e si vuole solo mostrare ai pazienti e ai malati il metodo di estrazione più sicuro seguendo l'unico studio pubblicato di recente sulla rivista "Cannabinoids" E' stato realizzato questo video tutorial che dimostra come produrre con gli utensili che usiamo in cucina, il cannabis oil, seguendo le ricette che potete scaricare gratuitamente dalla sezione medical info su www.lapiantiamo.it .
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Anxiety is a common mental health issue that affects millions of people worldwide. It can manifest in various ways, such as constant worrying, feelings of dread or unease, and physical symptoms like increased heart rate and muscle tension. Finding effective ways to manage anxiety is essential for improving one’s overall well-being and quality of life.
The Role of CBD Oil in Managing Anxiety:
Cannabidiol, commonly known as CBD, is a natural compound found in the cannabis plant. It has gained popularity in recent years for its potential therapeutic benefits, including its ability to reduce anxiety symptoms. CBD oil is derived from the hemp plant and is often used as a natural remedy for various health conditions, including anxiety disorders.
Research suggests that CBD interacts with the body’s endocannabinoid system, which plays a crucial role in regulating functions such as mood, stress response, and sleep. By influencing the endocannabinoid system, CBD may help alleviate anxiety symptoms and promote a sense of calm and relaxation.
Many people turn to CBD oil as a complementary therapy for managing anxiety, especially those who prefer natural and holistic approaches to their mental health. Unlike prescription medications, CBD oil is generally well-tolerated and has few reported side effects, making it a popular choice for those seeking alternative treatment options.
Choosing the Right CBD Oil for Anxiety Relief:
When considering CBD oil for anxiety relief, it is essential to choose a high-quality product from a reputable manufacturer. Look for CBD oils that are third-party tested for purity and potency to ensure you are getting a safe and effective product. It is also important to start with a low dose and gradually increase it as needed to find the optimal dosage for your individual needs.
Additionally, consider the type of CBD oil you are using – full-spectrum, broad-spectrum, or CBD isolate. Full-spectrum CBD oil contains other beneficial compounds found in the cannabis plant, such as terpenes and flavonoids, which may enhance the overall therapeutic effects of CBD. Broad-spectrum CBD oil is similar to full-spectrum but contains no THC, making it a suitable option for those who want to avoid the psychoactive effects of THC.
When using CBD oil for anxiety relief, it is essential to be patient and consistent with your dosing regimen. It may take some time for the effects of CBD to become noticeable, so give it a few weeks to see how it impacts your anxiety symptoms. Keep track of your progress and adjust your dosage as needed to find the best results.
Benefits of Using CBD Oil for Anxiety Relief:
There are several potential benefits of using CBD oil for anxiety relief. Some studies suggest that CBD may help reduce symptoms of generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder. CBD oil may also help improve sleep quality, reduce stress, and promote a sense of overall well-being.
Many people find that using CBD oil for anxiety relief allows them to manage their symptoms effectively without the need for prescription medications or other conventional treatments. CBD oil is considered a safe and natural remedy that can be used alone or in conjunction with other therapies to support mental health and well-being.
It is important to note that while CBD oil shows promise for anxiety relief, it is not a cure-all solution. It is essential to consult with a healthcare provider before starting any new treatment regimen, especially if you are already taking other medications or have underlying health conditions. With the right approach and guidance, CBD oil can be a valuable tool in navigating anxiety relief and improving overall quality of life.
FAQs About Using CBD Oil for Anxiety Relief:
1. Is CBD oil legal?
Yes, CBD oil derived from hemp containing less than 0.3% THC is legal in most states in the US. However, it is essential to check the laws in your specific state or country before purchasing or using CBD oil.
2. How should I take CBD oil for anxiety relief?
CBD oil can be taken orally, sublingually, topically, or inhaled through vaping. The best method for you may depend on your personal preferences and the severity of your anxiety symptoms. It is recommended to start with a low dose and gradually increase it as needed.
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3. Are there any side effects of using CBD oil?
While CBD oil is generally well-tolerated, some people may experience side effects such as dry mouth, dizziness, fatigue, or changes in appetite. It is essential to talk to your healthcare provider if you experience any adverse reactions while using CBD oil.
4. Can I get addicted to CBD oil?
CBD is not addictive and does not produce the euphoric effects associated with THC. It is considered safe for long-term use and does not pose a risk of dependency or substance abuse.
5. How long does it take for CBD oil to work for anxiety relief?
The effects of CBD oil can vary depending on the individual and the dosage used. Some people may experience immediate relief, while others may need to use CBD oil consistently for several weeks to notice significant improvements in their anxiety symptoms.
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