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Dank Network in partnership with Leafbuyer presents: THCa vs. THC As marijuana use in the US continues to rise, medical and recreational marijuana markets are being adjusted to further protect public health. More test are being done, leading consumers into a retail environment where the potency of various plant compounds, known as cannabinoids, are represented in percentages. T-H-Ca and T-H-C are the two cannabinoids most directly relating to the ‘high’ users receive. The macroeconomic inertia behind this emerging industry has forced state and federal government agencies and private research firms, among others, to invest firmly in research of the plant, resulting in solid evidence cannabinoids, the various plant compounds producing the varied biological effects cannabis is known for, can have very different effects on the mind and body of humans and animals. One analysis of the differences by Kate Welch, a doctoral recipient and pharmacist, suggest both THCa and THC interact with the immune and nervous system, as well as various parts of the brain, yet the mechanism or route THCa and THC use to produce the biological effects is incredibly different - sometimes. So…. What does it means to convert THCa to THC? Expressing the differences between the two plant compounds can be done by examining the two cannabinoids at the molecular level. THCa is the carboxylic acid form of THC. With regard to THCa, a carboxylic acid describes the molecular structure including a carbon and oxygen molecule. Under normal circumstances, this prevents the psychoactive THC from being readily available. THCa, much like both CBDa and CBD, produces no psychoactive ‘high’ or related euphoria. The process of removing the carbon and oxygen molecules is done simply by adding heat. this is why eating raw marijuana will not get you stoned, but smoking or otherwise heating it will. It is also important to note laboratory labels on medical or recreational cannabis usually lists both THCa and THC concentrations. If the THCa is testing at 18% and the THC is testing at 1.5%, it may be easily assumed the product - once activated by heat - will be 19.5% THC. This is inaccurate. THCa percentages must be multiplied by the molecular mass of THC before being translated into final THC potential. Interestingly, the analysis released by Kate Welch the pharmacist, suggests THCa can produce at least two clinically significant outcomes more effectively than THC can. THe First being that -- THCa and THC can both provide anti-nausea and anti-vomiting effects, yet research suggests THC is less potent than THCa. In rat studies, the effect of THCa on nausea and vomiting is described as ‘considerable’ and was shown to inhibit these effects by activating serotonin receptors. #2... THCa is more effective than THC at managing inflammation, pain THCa and THC both have clinical potential as an anti-inflammatory and pain reliever, having even been shown to engage similar biological pathways to achieve this effect as ibuprofen or aspirin. Additionally, THCa may work better than THC as a neuroprotective In animal studies. research on the cannabinoids THCa and THC, has suggested the cannabinoid may have a neuroprotective effect.. What That means is cells, rather than degenerating, are encouraged to continue along healthfully. In so doing, this slows the rate an illness such as Parkinson’s disease can radicalize cells. Individuals with neurodegenerative diseases such as Parkinson's have been seeking beyond the realm of traditional western medicine and turning to medical marijuana for their condition, which currently has no cure. Remember, Live Higher!
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CBD Based Hemp CannabisStory of Charlotte’s Web Who was Charlotte Figi? Charlotte Figi, a child with a catastrophic type of epilepsy. She became a symbol of the positive impacts that CBD can have. Charlotte had Dravet syndrome, a rare form of epilepsy Sadly she passed away April 7th, 2020 at the age of 13 Cause of death thought to be pneumonia Rare Form of Epilepsy (Dravet syndrome) Dravet syndrome, a rare form of epilepsy where the seizures start during the first year of life. Charlotte at the age of 6 was having a seizure every 30min. Over Two Years Her Parents (Paige and Matt) Tried… Diet alterations Acupuncture Drugs (Ex. Valent, Adavan, Penabarbrotol) Some medications nearly lead to her death (beathing and heart stopping) With no changes from any of the above. At peak Charlotte was having 300 seizures a week (~2 per hour) and was not talking or moving Doctors had provided two options… Veterinary drug used on epileptic dogs Medically induced coma Half a World Away… Father Matt was deployed to Afghanistan and was researching online. He found evidence that cannabis can help reduce seizures The Stanley Brothers The Stanley brothers, marijuana growers in Colorado, were crossbreeding a strain of marijuana high in CBD and low in THC, its psychoactive ingredient. Their focus was the breed down the THC and up the CBD They were able to achieve a CBD level of 21% while still maintaining a THC level under 1%. Reason was not for recreational smoking, but for its potential medical benefits Flower to Extraction Mother went to a local Denver, CO dispensary and purchased some high CBD variety cannabis. Owner was surprised of the request since nobody wanted it because it did not have any effect. Low THC and High CBD Thought to potentially be “R4”: THC: 0.76% and CBD: 17.61% After taking the flower home she extracted the CBD Impact of CBD Treatment The day she was given a CBD oil treatment under the tongue she did not have a seizer that day which continued into the night and beyond. Overall there was a sharp decline in seizures. She went from 300 seizures a week to only have 1 a week! She went from a feeding tube to eating on her own She started talking and also walking Does: Charlotte’s Web = CW2A (?) According to the U.S. Patent and Trademark Office, Joel Stanley filed the patent application in May 2018 on behalf of his company, also named Charlotte’s Web. In the public documents, Stanley described a plant type capable of producing 6.24-percent CBD content and 0.27-percent THC content. The patent was approved in July 2019 “The new cultivar of ‘CW2A’ was asexually reproduced via stem cuttings from vegetative and/or flowering plants, and cloning by the inventor at the inventor’s greenhouses, nurseries, fields and/or facilities in Colorado Springs, Colo., and Wray, Colo.,” according to the patent. “Asexual clones from the original source have been tested in greenhouses, nurseries, and/or fields. The properties of each clone from this cultivar were found to be transmissible by such asexual reproduction. The cultivar is stable and reproduces true to type in successive generations of asexual reproduction.” Plant Patent Specifics The patent issued to CWB Holdings is a plant patent, not a broader utility patent This means it is good only for legal protection against a competitor growing the same cultivar from clone. Even though this may be overall limited protection it is groundbreaking in that this is the first and only plant patent for a hemp cultivar issued in the United States. Value of a Patent The patent does not prevent others from developing their own strain of similar characteristics. The goal from the breeders stand point is to protect the strain you have put time and resources into developing. The patent does not prevent competition, but can provide an advantage in the market. Charlotte’s Web Specifics Sativa based strain with a stated 13% CBD However, patent states 6.24% CBD and 0.29% THC These unique and proprietary genetics are used by Charlotte's Web (the company) to create extracts for a variety of health and wellness products. Contrary to popular belief, Charlotte’s Web products are hemp-derived and are non-intoxicating. New consumers should consult their doctor with any medical concerns. Link to Lecture Slides: https://drive.google.com/file/d/1p_Fndnj4Ypl050Fs0idAHQczIB9hh2a-/view?usp=sharing *Due to the description character limit the full work cited for "CBD Based Hemp Cannabis Story of Charlottes Web" can be viewed at... https://drive.google.com/file/d/1kbRR2BLwpxrckZg96HiEPaHwa_mSXJ7r/view?usp=sharing
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Delta 9 Hemp Gummies have been gaining popularity in recent years as a natural alternative to traditional medications for various health concerns. These gummies are infused with cannabidiol (CBD), a compound found in hemp plants known for its therapeutic properties. Unlike marijuana, hemp-derived CBD products like Delta 9 Hemp Gummies contain minimal amounts of tetrahydrocannabinol (THC), the psychoactive component that produces a “high.”
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As the popularity of Cannabidiol (CBD) continues to rise, it is crucial to understand the regulations and guidelines set by the Food and Drug Administration (FDA) when it comes to the use and sale of CBD products. The FDA plays a vital role in ensuring the safety and efficacy of products consumed by the public, including CBD products. By examining the FDA’s perspective on CBD, we can gain insight into the regulations that govern this rapidly growing industry.
The Legal Status of CBD
One of the key areas of concern for the FDA is the legal status of CBD. While CBD derived from hemp is legal at the federal level under the 2018 Farm Bill, the FDA has not yet approved CBD as a dietary supplement or food additive. This means that companies cannot market CBD products as dietary supplements or add CBD to food and beverages. The FDA has expressed concerns about the potential risks associated with long-term CBD use, such as liver injury and drug interactions.
Additionally, the FDA has issued warning letters to companies making unsubstantiated health claims about CBD products. These claims include curing cancer, Alzheimer’s disease, and other serious medical conditions. The FDA has stressed the importance of conducting rigorous scientific research to support any health claims associated with CBD.
Quality Control and Labeling
Another area of focus for the FDA is ensuring the quality and safety of CBD products. The FDA has conducted several studies that have found discrepancies between the labeled and actual levels of CBD in products. This lack of consistency raises concerns about the efficacy of CBD products and the potential for consumers to be misled.
The FDA has also raised concerns about the presence of contaminants in CBD products, such as heavy metals, pesticides, and solvents. These contaminants can pose serious health risks to consumers, especially those with compromised immune systems or underlying health conditions. The FDA emphasizes the importance of proper testing and quality control measures to ensure the safety of CBD products.
Marketing and Advertising
When it comes to marketing and advertising CBD products, the FDA has strict guidelines in place to protect consumers from false or misleading claims. Companies are prohibited from making claims that their products can diagnose, treat, cure, or prevent any disease without sufficient scientific evidence to support these claims.
The FDA has also warned against marketing CBD products for use in vulnerable populations, such as children or pregnant women, due to the lack of research on the potential risks associated with CBD use in these groups. Companies that fail to comply with these guidelines may face enforcement actions from the FDA, including warning letters, product seizures, and injunctions.
Regulatory Oversight
As the CBD industry continues to expand, the FDA faces the challenge of regulating a rapidly evolving market. The FDA is working to develop clear guidelines and regulations for the manufacturing, testing, and labeling of CBD products to ensure consumer safety and product quality.
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The FDA is also collaborating with other federal agencies, such as the Drug Enforcement Administration (DEA) and the Department of Agriculture, to coordinate efforts and streamline regulations across different sectors of the CBD industry. By working together, these agencies can establish a comprehensive regulatory framework that protects consumers while allowing for innovation and growth in the CBD market.
Research and Development
One of the FDA’s priorities is to support and promote research on the potential benefits and risks of CBD. The FDA encourages companies to conduct clinical trials to evaluate the safety and efficacy of CBD products for various medical conditions. This research is essential for providing the scientific evidence needed to support health claims and inform regulatory decisions.
The FDA also collaborates with academic institutions, research organizations, and industry partners to advance our understanding of CBD and its effects on the body. By promoting research and development in this area, the FDA aims to provide consumers and healthcare professionals with accurate information about the potential benefits and risks of CBD products.
Understanding the FDA’s perspective on CBD is essential for consumers, healthcare professionals, and industry stakeholders alike. By following the FDA’s guidelines and regulations, we can ensure the safety, quality, and efficacy of CBD products on the market. As the CBD industry continues to evolve, it is important to stay informed about the latest developments and regulations set forth by the FDA.
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