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💉Mounjaro (ZepBound) weight loss results, check out my results for January plus some tips! ⚖️ In this video, I cover my weight loss results for January on Mounjaro. Covering from Christmas day all the way to the end of January! Plus, there are some more question & answers and a few tips too from myself and the community. I hope you're still enjoying the journey so far, there is much more to come. 😀👍 Intro to my Journey - https://youtu.be/BsppF3XlPmM Week 1 & 2 Results - https://youtu.be/vun9toVFveo Week 3 & 4 Results - https://youtu.be/cSV4a1nQuWY Week 5 & 6 Results - https://youtu.be/vpSDs0BMYnI Follow along as I detail my weight loss progress and fitness journey, specifically my experiences with the weight loss drug Mounjaro (also known as Zepbound in the USA). Mounjaro is the brand name for Tirzepatide which works similarly to Weygovy and Ozempic by manipulating your GLP-1 and GIP receptors. I hope you enjoy it, and if so, like and subscribe, and the next video will cover my first month of issues on Mounjaro! Thanks! 😀👍 #mounjaro #zepbound #weightloss Chapters:- ⌚ 00:00 - Intro 01:28 - Questions, Answers & Tips 02:20 - Reasons to Subscribe 09:00 - January Update 13:40 - Results 15:07 - A Look Ahead

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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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Free Calorie Calculator - https://ericrobertsfitness.com/free-calorie-calculator/ Lose Fat With Personalized 1:1 Coaching - https://theclubhouse1.lpages.co/1to1-coaching . . . . . 0:00 – The Fat Loss “Cheat Codes” No One Talks About 0:42 – Why Subtracting Food Might Work Better Than Adding It 2:30 – The 10-Minute Trick to Kill Cravings Fast 4:24 – The Progress Hack That Works Better Than the Scale 6:16 – Win Before Breakfast with This 90-Second Routine 7:32 – The Motivation Hack That Turns Dieting Into a Game 9:55 – Why Grazing All Day Keeps You Fat 12:59 – This is Where Most People Actually Ruin Their Diet 14:45 – One Meal Swap That Cuts Cravings All Day 16:37 – Make Faster Progress by Doing Less 18:40 – The “Plan B” That Keeps You on Track When Life Falls Apart 21:00 – Want Even Easier Hacks? Watch This Next

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