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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
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The popularity of the ketogenic diet has led to the introduction of various supplements claiming to enhance fat burning and weight loss. One such product is Keto Extreme Fat Burner, which promises to support ketosis and help users achieve their weight loss goals. With so many similar products on the market, it can be challenging to determine which ones are effective and worth trying. In this article, we will evaluate Keto Extreme Fat Burner by examining its claims, ingredients, and customer reviews to help you make an informed decision about whether it is the right choice for you.
Ingredients in Keto Extreme Fat Burner
Keto Extreme Fat Burner contains a proprietary blend of ingredients that are intended to promote ketosis and fat burning. Some of the key ingredients in this supplement include beta-hydroxybutyrate (BHB), MCT oil, and green tea extract. BHB is a ketone body that is produced during the metabolic process of ketosis, while MCT oil is a type of fat that is quickly absorbed by the body and converted into energy. Green tea extract is known for its antioxidant properties and ability to boost metabolism.
Each of these ingredients is believed to play a role in supporting weight loss and fat burning. BHB helps to increase ketone levels in the body, which can lead to faster fat burning and weight loss. MCT oil provides a quick source of energy for the body, which can help to sustain energy levels during workouts and throughout the day. Green tea extract contains compounds that may help to increase metabolism and promote fat oxidation.
While these ingredients have shown promise in promoting weight loss, it is important to note that individual results may vary. Some users may experience significant weight loss while taking Keto Extreme Fat Burner, while others may not see the same results. It is always recommended to consult with a healthcare provider before starting any new supplement regimen to ensure it is safe and appropriate for your individual needs.
Customer Reviews and Feedback
Customer reviews and feedback can provide valuable insights into the effectiveness of a product like Keto Extreme Fat Burner. Many users have reported positive results from taking this supplement, including increased energy levels, reduced cravings, and significant weight loss. Some users have noted that they were able to reach ketosis faster and maintain it for longer periods while taking Keto Extreme Fat Burner.
However, not all reviews of Keto Extreme Fat Burner are positive. Some users have reported experiencing side effects such as digestive issues, headaches, and feelings of jitteriness. It is important to consider these potential side effects when deciding whether to try this supplement, as they may impact your overall experience and results. As with any supplement, it is recommended to start with a lower dose and gradually increase as tolerated to minimize potential side effects.
In conclusion, Keto Extreme Fat Burner offers a combination of ingredients that are believed to support ketosis and weight loss. While many users have reported positive results from taking this supplement, individual experiences may vary. It is essential to consider the potential benefits and risks of using Keto Extreme Fat Burner and to consult with a healthcare provider before starting any new supplement regimen. With the right approach and realistic expectations, Keto Extreme Fat Burner could be a helpful addition to your weight loss journey.
Final Thoughts and Recommendations
In summary, Keto Extreme Fat Burner is a popular supplement that claims to support ketosis and enhance weight loss. Its key ingredients, including BHB, MCT oil, and green tea extract, are believed to promote fat burning and metabolism. While many users have reported positive results from taking this supplement, individual experiences may vary, and some users may experience side effects such as digestive issues or headaches. It is essential to consider these factors when deciding whether to try Keto Extreme Fat Burner and to consult with a healthcare provider before starting any new supplement regimen.
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Overall, Keto Extreme Fat Burner could be a helpful addition to your weight loss journey if used in conjunction with a healthy diet and regular exercise routine. Remember to set realistic goals and expectations, and listen to your body to determine what works best for you. With the right approach, Keto Extreme Fat Burner may help you reach your weight loss goals and support your overall health and wellness.
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Have you ever wondered what goes on behind the scenes of your favorite reality TV shows? One of the most popular shows, Shark Tank, gives entrepreneurs the opportunity to pitch their business ideas to a panel of wealthy investors with the hope of securing funding. Keto Complete, a keto supplement company, recently made an appearance on Shark Tank, captivating viewers with their innovative product and compelling pitch. In this article, we’ll take a closer look at Keto Complete’s experience on Shark Tank and reveal what really goes on behind the scenes of the hit show.
The Pitch
When the founders of Keto Complete stepped onto the Shark Tank stage, they were met with eager anticipation from both the investors and the audience. Their pitch highlighted the benefits of their keto supplement, emphasizing its ability to help individuals reach their weight loss goals and improve their overall health. The founders shared their personal journey of discovering the ketogenic diet and how it inspired them to create Keto Complete as a way to make the diet more accessible to others.
The investors were impressed by the founders’ passion and knowledge of the keto diet and were intrigued by the potential of Keto Complete’s product. They asked probing questions about the supplement’s ingredients, manufacturing process, and market potential. The founders confidently answered each question, showcasing their expertise in the industry and reinforcing the value of their product.
As the pitch continued, tension mounted as the investors deliberated on whether or not to make an offer. Viewers at home watched with bated breath as the investors weighed the risks and rewards of investing in Keto Complete. In the end, a deal was struck, and Keto Complete secured the funding they needed to take their business to the next level. The founders celebrated their success, grateful for the opportunity to partner with one of the Shark Tank investors.
Behind-the-Scenes Secrets
While Shark Tank presents a polished and edited version of the entrepreneurs’ pitches, there is a lot that happens behind the scenes that viewers don’t see. Before appearing on the show, entrepreneurs undergo rigorous preparation, working closely with the producers to perfect their pitch and anticipate any questions the investors may ask. This preparation is crucial in ensuring that the entrepreneurs make a strong impression and increase their chances of securing a deal.
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On the day of filming, nerves are running high as the entrepreneurs wait backstage for their turn to pitch to the investors. The energy in the room is palpable as each entrepreneur steps onto the stage, hoping to make a lasting impression on the investors. The pitch itself is just the tip of the iceberg, with hours of filming and deliberation condensed into a short segment for viewers to see.
After the pitch is over, the entrepreneurs face a grueling negotiation process as they try to strike a deal with the investors. This negotiation can last for hours, with the investors digging deep into the entrepreneurs’ business model, financials, and future plans. The entrepreneurs must stay on their toes, thinking quickly and strategically to secure the best possible deal for their company.
Post-Show Success
For Keto Complete, appearing on Shark Tank was a game-changer, opening up new opportunities and propelling their business to new heights. The exposure from the show helped Keto Complete increase brand awareness and reach a larger audience of potential customers. The funding they received allowed them to scale their operations, improve their product, and expand into new markets.
Since their appearance on Shark Tank, Keto Complete has experienced significant growth, becoming a trusted name in the keto supplement industry. They continue to innovate and develop new products to meet the needs of their customers, staying true to their mission of helping individuals achieve their health and wellness goals. The founders look back on their time on Shark Tank with gratitude, knowing that the show played a crucial role in their success.
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In the world of health and wellness, dietary supplements continue to gain popularity, with many individuals seeking innovative solutions to aid weight loss and improve overall well-being. Among these, Boostline Keto ACV Gummies have emerged as a notable option, catching the attention of those pursuing a ketogenic lifestyle. Launched as a convenient and flavorful alternative to traditional dietary supplements, these gummies combine the principles of the ketogenic diet with the benefits of apple cider vinegar (ACV). The year 2025 has seen an influx of reviews and testimonials from users, each reflecting their unique experiences with the product, its effectiveness, and potential drawbacks.
The ketogenic diet focuses on reducing carbohydrate intake and replacing it with fats, promoting a metabolic state known as ketosis. When the body enters ketosis, it becomes remarkably efficient at burning fat for energy, leading to weight loss and increased energy levels. The inclusion of apple cider vinegar in these gummies is believed to further enhance the weight loss process, as ACV has been known to curb appetite, improve digestion, and regulate blood sugar levels. This dual approach makes Boostline Keto ACV Gummies an intriguing option for those looking to embark on or support their weight loss journey.
With the surge in demand for such products, buyers are keen on understanding whether Boostline Keto ACV Gummies live up to their claims. As potential customers explore various reviews, they often seek honest opinions from individuals who have incorporated these gummies into their routines. This article dives deep into the reviews gathered throughout 2025, focusing on ten diverse perspectives from real buyers. By examining both the positive and negative feedback, we aim to provide a balanced overview that can help prospective purchasers make informed decisions about this trending product.
Real Experiences: Positive Feedback from Users
Many users rave about their experiences with Boostline Keto ACV Gummies, citing significant benefits that align with their health goals. Several customers reported noticeable weight loss after regularly adding the gummies to their dietary routine. One buyer mentioned that the gummies complemented her existing keto diet, making it easier to stick to her plan while enjoying a sweet treat. Users often appreciate the convenience of gummies compared to liquid ACV, which some find unpalatable. The taste and texture of the gummies have been highlighted as a major advantage, making them an appealing option for those who typically dislike the more traditional forms of apple cider vinegar.
Some users also mentioned improvements in their energy levels and mental clarity after incorporating Boostline Keto ACV Gummies into their daily regimen. One reviewer shared that she experienced more sustained energy throughout her workouts, allowing her to push harder and achieve her fitness objectives. Enhanced focus and cognitive support are also benefits cited by several individuals, particularly those juggling multiple responsibilities. These positive experiences resonate with those looking for effective ways to boost their energy and maintain focus while pursuing a healthy lifestyle.
Moreover, Boostline Keto ACV Gummies have been endorsed for their appetite-suppressing qualities. Many users expressed how the gummies effectively curbed their cravings for unhealthy snacks, which has proven beneficial for weight management. One buyer stated that incorporating the gummies into her diet helped her resist the temptations of high-carb snacks that previously derailed her progress. This particular feature, coupled with positive experiences, contributes to the growing popularity of the product among those committed to their health journeys.
Calls for Caution: Negative Experiences Shared
<pWhile many users have reported positive outcomes, it is crucial to address that not everyone shares the same enthusiasm regarding Boostline Keto ACV Gummies. A significant portion of negative reviews focuses on the product's perceived ineffectiveness. Some individuals remarked that, despite consistent use, they did not see any tangible weight loss results. These users emphasized that while the gummies were enjoyable to eat, they did not deliver the expected benefits in terms of weight management or energy levels. This discrepancy highlights the importance of individual differences when it comes to dietary supplements.
<pSide effects have also been mentioned in various reviews, leading some consumers to express their concerns. A few buyers reported experiencing stomach discomfort and digestive issues after consuming the gummies, prompting them to discontinue use. It is essential for consumers to be aware that dietary supplements can react differently based on individual health circumstances and sensitivities. Therefore, those considering Boostline Keto ACV Gummies should approach them with caution, particularly if they have pre-existing health conditions or are sensitive to apple cider vinegar.
<pAnother area of concern includes the formulation of the gummies. Some users have criticized the ingredient list, specifically noting high sugar content and synthetic additives that may not align with their health-oriented objectives. Buyers who follow strict dietary guidelines expressed disappointment when they discovered that the gummies contained more sugar than they anticipated, leading them to question whether these gummies truly fit within their keto lifestyle. Such negative feedback serves as a reminder that consumers must carefully evaluate products to ensure they align with their personal health goals.
The Ingredients: What Makes These Gummies Unique?
<pAt the heart of any dietary supplement lies its ingredients, and Boostline Keto ACV Gummies are no exception. One of the standout components is apple cider vinegar, which is well-known for its myriad health benefits. ACV is believed to support weight loss by enhancing metabolism, reducing appetite, and promoting fat burning. When combined with a ketogenic approach, the effects can be amplified, making these gummies particularly appealing for those seeking to integrate ACV into their diet without the harsh taste of liquid vinegar.
<pIn addition to apple cider vinegar, the gummies are infused with other natural ingredients that complement their purported benefits. For instance, many formulations include natural flavors and colors derived from fruits and vegetables, making them a more palatable choice. Some variants may even feature added vitamins or minerals, enhancing their nutritional profile and providing additional health benefits. Buyers often appreciate this aspect, as it reinforces the perceived value of including these gummies in a holistic health regimen.
<pWhile the combination of apple cider vinegar and additional natural components leads many to believe in their efficacy, it also raises some questions. Potential buyers are encouraged to scrutinize the ingredient list and research any unfamiliar components. Transparency in labeling can significantly affect a customer’s trust and willingness to purchase, especially in a market flooded with dietary supplements. Therefore, users are advised to assess whether the ingredients align with their unique health needs and dietary restrictions before making a purchase.
Cost Considerations and Purchasing Options
<pWhen evaluating any dietary supplement, cost is often a significant factor that influences purchasing decisions, and Boostline Keto ACV Gummies are no exception. Buyers should consider both the price point and the quantity offered in each package. Many find that while the initial investment may be relatively moderate, the perceived value largely depends on the individual’s budget and willingness to spend on health supplements. Some users have commented on the affordability of the gummies compared to other popular weight-loss products on the market.
<pAvailability also plays a crucial role in the purchasing experience. Many users have reported positive experiences when buying Boostline Keto ACV Gummies directly from the brand's website or certified online retailers. This ensures that customers are getting authentic products, which can be a concern with dietary supplements. Additionally, purchasing directly from the brand may sometimes reveal special offers, such as discounts for bulk orders or subscription models that enhance value. Therefore, it benefits buyers to explore various purchasing avenues before finalizing an order.
<pIt’s also essential for consumers to factor in shipping costs and potential delays in their decision-making process. A few customers have expressed frustration over shipping times, particularly if they were eager to receive their products quickly. Understanding the shipping policies of the retailer and evaluating customer service response times can mitigate disappointment and ensure a smoother purchasing experience. Taking all of these factors into consideration will help buyers make a more informed choice about whether Boostline Keto ACV Gummies fit into their budget and health goals.
Your Questions Answered: Key Takeaways from User Reviews
<pNavigating the myriad of opinions surrounding Boostline Keto ACV Gummies can often leave potential buyers with several questions. One common inquiry revolves around the timeframe for expected results. Many users agreed that substantial changes, such as weight loss, could take several weeks of consistent use. Factors such as individual metabolism, dietary habits, and exercise routines play crucial roles in this timeframe. Hence, it is essential for users to approach these gummies as a supplement to a broader lifestyle change aimed at enhancing weight loss.
<pAnother frequent question relates to the potential side effects of the gummies. As discussed in prior sections, while many buyers experienced no adverse effects, some reported digestive discomfort. It is advisable for new users to start with half the recommended dosage to assess their tolerance before fully committing to the product. In cases of persistent side effects, discontinuing use and consulting with a healthcare professional can help clarify whether the product aligns with individual health needs.
<pLastly, potential buyers often wonder whether Boostline Keto ACV Gummies require a strict ketogenic diet to be effective. While the gummies leverage ketogenic principles, many users have found them beneficial even when not strictly adhering to these dietary guidelines. However, the best results may indeed be found by combining the gummies with a careful diet and exercise regimen. The consensus among users is that while the gummies are a helpful tool, they are most effective when used as part of a comprehensive health strategy.
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Hydroxycut is a weight loss supplement with a dangerous past. We expose the serious side effects and risks associated with Hydroxycut Original / Pro Clinical, including at least one death. Is this supplement worth the risk? For more information about this topic: https://brianyeungnd.com/2022/12/08/does-hydroxycut-original-pro-clinical-work/ Get EXCLUSIVE content and SUPPORT us: https://ko-fi.com/brianyeungnd Top recommended alternatives to Hydroxycut Original / Pro Clinical: ACV (caps) - https://amzn.to/3OSBMHB - 10 to 20 caps / day ACV (liquid) - https://amzn.to/3OvA3H1 - 1 to 2 tbsp / day Caffeine anhydrous - https://amzn.to/3ORMLRN - 1 cap / day Green coffee (caps) - https://amzn.to/3KACRBu - 1 to 2 caps / day Vitamin D (caps) - https://amzn.to/3OnMxQQ - 1 to 2 caps / day Vitamin D (drops) - https://amzn.to/3OrRpo9 - 1 to 2 drops / day 0:00 Intro 1:19 Ingredients of Hydroxycut Original 1:28 Hydroxycut Original vs Pro Clinical Hydroxycut 2:31 Vitamin D 3:16 B vitamins 3:54 Green coffee bean 4:27 Apple cider vinegar 5:03 Plum 5:16 Baobab and cardamom 5:40 Caffeine 6:50 Side effects and warnings 9:03 Is Hydroxycut Original effective? 9:34 Is Hydroxycut Original worth it? 10:28 Overall rating **************** Learn more about: Green Coffee Bean Extract For Weight Loss: https://youtu.be/WoiLOJiiRQA Apple Cider Vinegar for Weight Loss: https://youtu.be/zyUWTjajXfI Is Caffeine Good For Weight Loss? https://youtu.be/hmqt-j1Odew 6 Things To Look For On Supplements: https://youtu.be/zTwGrbIF80k 5 Things to Know Before Buying Weight Loss Supplements: https://youtu.be/4ZNlqj-yVHQ Dr. Brian Yeung, ND: https://brianyeungnd.com/about/ **************** DISCLAIMERS Affiliate links: Please keep in mind that we may receive a commission when you click on our links and make a purchase. This, however, has no bearing on our reviews and comparisons. Content: All statements made are opinions and not stated as fact. While Dr. Brian and his team makes every effort to fact check the information presented, mistakes can still be made. Dr. Brian and his team are not responsible for any errors or omissions in the information provided. The intent of this channel is not to malign or harm the reputation of any individual, company, or organization. All criticisms are made in good faith and with the aim of providing constructive feedback. Copyright: All content, including but not limited to videos, designs, and captions, produced by Dr. Brian is protected under copyright law. Any unauthorized reproduction, distribution, or display of our content, in part or in whole, is strictly prohibited. We do not give permission for anyone to translate and/or reupload our videos, designs, or captions on YouTube or other social media platforms. Any such activity will be considered a violation of our intellectual property rights and may result in legal action. Medical: Dr. Brian Yeung, ND received his Doctor of Naturopathic Medicine degree from the Canadian College of Naturopathic Medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Yeung is currently a practicing Naturopathic Doctor with additional prescribing authority and IV therapy certification in Ontario. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Yeung and you. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. BrianYeungND and Dr. Brian Yeung, ND are not liable or responsible for any advice, course of treatment, diagnosis or any conclusions drawn, services or product you obtain through this video or site.
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