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Semaglutide is a medication that has gained popularity for its effectiveness in aiding weight loss. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists, which work by increasing feelings of fullness and slowing down digestion. Semaglutide was initially approved for the treatment of type 2 diabetes, but researchers discovered that it also helps with weight management. In 2021, the U.S. Food and Drug Administration (FDA) approved a higher dose of Semaglutide specifically for weight loss in individuals with a body mass index (BMI) of 30 or higher, or with a BMI of 27 or higher who have weight-related conditions such as high blood pressure, high cholesterol, or type 2 diabetes.
Understanding the Common Side Effects of Semaglutide for Weight Loss
While Semaglutide can be an effective tool for weight management, it is essential to understand the potential side effects that may accompany its use. Like any medication, Semaglutide can cause unwanted reactions in some individuals. It is crucial to be aware of these side effects and know when to seek medical attention. Here are some of the common side effects associated with Semaglutide for weight loss:
Gastrointestinal Issues
One of the most commonly reported side effects of Semaglutide is gastrointestinal problems. These may include nausea, vomiting, diarrhea, and constipation. These symptoms typically occur during the first few weeks of treatment and may improve over time as your body adjusts to the medication. It is essential to stay hydrated and eat small, frequent meals to help alleviate these side effects. If you experience severe or persistent gastrointestinal issues, consult your healthcare provider.
Hypoglycemia
Semaglutide works by lowering blood sugar levels, which can sometimes lead to hypoglycemia, or low blood sugar. Symptoms of hypoglycemia may include dizziness, sweating, shakiness, confusion, and rapid heartbeat. It is crucial to monitor your blood sugar levels regularly while taking Semaglutide, especially if you are also using other medications that can lower blood sugar. If you experience symptoms of hypoglycemia, consume a fast-acting source of glucose, such as fruit juice or glucose tablets, and seek medical attention if necessary.
Injection Site Reactions
Since Semaglutide is administered via injection, it is not uncommon to experience mild reactions at the injection site, such as redness, swelling, or itching. These symptoms are usually temporary and should resolve on their own. To minimize discomfort, rotate injection sites and follow proper injection techniques as instructed by your healthcare provider. If you notice severe or persistent reactions at the injection site, contact your healthcare provider.
Decreased Appetite
Another common side effect of Semaglutide is a decreased appetite. While this can be beneficial for weight loss purposes, it may also lead to inadequate calorie intake if not managed properly. It is essential to focus on nutrient-dense foods and listen to your body’s hunger cues to ensure you are meeting your nutritional needs. If you experience significant appetite reduction or unintentional weight loss, consult your healthcare provider for guidance.
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In clinical trials, Semaglutide has been associated with an increased risk of thyroid tumors, specifically thyroid C-cell tumors, in rodent studies. While the relevance of this finding to humans is not fully understood, it is essential to monitor for any symptoms of thyroid tumors, such as neck swelling, difficulty swallowing, or changes in voice. Your healthcare provider may recommend periodic monitoring of thyroid function tests to detect any potential issues early on.
Summary and FAQ
In conclusion, Semaglutide can be an effective tool for weight loss, but it is essential to be aware of the potential side effects that may accompany its use. Gastrointestinal issues, hypoglycemia, injection site reactions, decreased appetite, and thyroid tumors are among the common side effects associated with Semaglutide. It is crucial to work closely with your healthcare provider to monitor for any adverse reactions and address them promptly.
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REFERENCE for Curious Interested Listeners & Physicians 48,25mar In Part 2 of our deep dive into Mounjaro vs. Ozempic, we’re busting myths and uncovering what doctors aren’t always saying. Here’s what we’ll cover: • Myth 1: “All GLP-1 drugs are the same.” • Reality: Ozempic targets a single pathway, while Mounjaro works on two—leading to potential greater weight loss in some, but it’s not a one-size-fits-all. • Myth 2: “These drugs only make you eat less.” • Reality: They also influence the brain’s reward system, reducing cravings and the emotional drivers of eating, not just physical hunger. We’ll break down how these medications work, the real-world impact, and why individual responses vary. Stay tuned Part 3 for more insights into what doctors might not be telling you about these weight loss treatments! 1. Animal Studies Alhadeff AL, Rupprecht LE, Hayes MR. (2012). Glucagon-like peptide-1 receptor signaling in the ventral tegmental area attenuates food intake. Journal of Neuroscience, 32(25), 8112-8120. Showed GLP-1 drugs reduce food-seeking behavior by acting on brain reward areas. 2. Brain Reward Pathways Dickson SL, Shirazi RH, Hansson C, et al. (2012). The role of GLP‑1 receptor activation in the central regulation of energy balance and reward. Physiology & Behavior, 106(2), 231–238. Explains how GLP-1 receptors in the brain influence eating for pleasure, not just hunger. 3. Incretin Hormones Review Nauck MA & Meier JJ. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism. Details the dual role of GLP-1 in gut and brain signaling. 4. The SURPASS-2 Trial Jastreboff, A. M., et al. (2022). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Parallel-Group, Phase 3 Trial. This study and provided weight loss data for both tirzepatide (Mounjaro) and semaglutide (Ozempic). 5. The SURPASS Clinical Trials (Review and Meta-Analysis) Frías, J. P., et al. (2022). Insights from the SURPASS Clinical Trials: A Systematic Review and Meta-Analysis of Tirzepatide in Type 2 Diabetes. Diabetes, Obesity and Metabolism. Discusses how the additional GIP receptor activity might contribute to enhanced weight loss. 6. Eli Lilly (Mounjaro) https://www.lilly.com/news/media/media-kits/mounjaro https://mounjaro.lilly.com 7. Novo Nordisk (Ozempic) https://www.novonordisk.com.au/our-products-for-healthcare-professionals.html https://rss.medsinfo.com.au/no/pi.cfm?product=nopozemp
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🎉 **140 Pounds Down & Ready to React!** 🎉 Welcome to our channel! After an incredible journey of losing 140 pounds as a couple, my husband and I are excited to share some personal info about our GLP-1 journey. In today’s video, we’re diving into some interesting Reddit posts about **Zepbound**. 👉 **Don’t forget to:** 👍 Like this video if you enjoy our reactions 💬 Comment below with your favorite Zepbound stories or suggestions for future videos 🔔 Subscribe and hit the bell icon so you never miss an update! Join our community and let’s enjoy this adventure together. Thanks for watching! 00:00 Introduction to GLP-1 Health and Wellness 00:24 Meet Elissa and Jarrod: Our Weight Loss Journey 00:49 Reacting to Online Posts: Weight Loss Success Stories 02:15 Discussing Medical Advice and GLP-1 Medications 07:42 Hydration Tips and Favorite Drinks 09:55 Clothing Sizes and Weight Loss Experiences 17:32 Shopping Challenges and Finding the Right Fit 25:37 Wardrobe Overhaul: The Cost of Weight Loss 26:05 Weight Training and Body Changes 27:34 Reddit Story: People Commenting on Weight Loss 29:33 Alcohol and Health: Personal Experiences 31:38 GLP-1 Medications and Their Effects 37:33 Constipation Struggles and Solutions 43:22 Wrapping Up: Final Thoughts and Farewell #Zepbound #RedditReactions #WeightLossJourney #140PoundsDown #couplereaction
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