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Preparation for bariatric surgery can take time. Watch now to find out more about our clinically supervised process at the Carilion Clinic Weight Loss Center. Our weight loss experts and surgeons are here for you before, after and during your weight loss journey. To learn more and to find out if you are a candidate for weight loss surgery, visit CarilionClinic.org/weightloss or call 540-224-5170.

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Metabolic health is an increasingly prominent concern, attracting growing attention and research, particularly within the microbiome field. Akkermansia muciniphila, a key player in the gut microbiome, has emerged as a significant driver of both gut and metabolic health. It plays a pivotal role in supporting gut barrier integrity and the production of GLP-1, a hormone with profound metabolic benefits. Learn from Adam Perlman, MD, MPH, FACP, about the latest research uncovering the impact of keystone and novel probiotic strains on GLP-1 signaling, satiety, cravings, and probiotic avenues for metabolic support. Key points: • Learn the mechanisms by which the gut microbiome mediates metabolic health. • Understand how the gut-metabolism axis plays a critical role in natural GLP-1 production. • Learn the benefits of incorporating Akkermansia-based probiotics into clinical practice. —————————————————————————————————— Are you a healthcare practitioner? Consider signing up with Fullscript! https://router.fullscript.com/practitioner-signup/webinar Please note this webinar was previously recorded and hosts will not be able to respond to questions or comments after the scheduled LIVE Fullscript webinar date. Questions? Reach us at https://support.fullscript.com/ Make sure to follow us on: Facebook | https://facebook.com/fullscript Twitter | https://twitter.com/fullscriptHQ Instagram | https://instagram.com/fullscript Linkedin | https://linkedin.com/company/fullscript © Fullscript 2025. All rights reserved.

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https://cuddly.com/donate/4943889/mercedes/?utm_source=youtube&utm_medium=social&utm_campaign=organic Mercedes is a beautiful cat who has been struggling in silence. Volunteers first noticed her losing weight, and after observing her while eating, they discovered she was growling at her food and pawing at her mouth. Despite having dental work done previously, her symptoms persisted, leading us to believe the issue was not fully addressed. After careful observation and consultation, it became clear that Mercedes might have leftover tooth roots under her gum line from her previous dental procedures. These roots, which were not fully addressed in her past dental work, have likely become inflamed and painful, making it difficult for Mercedes to eat and causing her to grow weaker. In addition, Mercedes may be suffering from stomatitis, a chronic inflammation of the gums, which often requires the removal of teeth to relieve the pain. We’re getting Mercedes into our trusted vet this week for a full evaluation and treatment plan. Her journey to recovery may require more dental work, including the potential removal of all her remaining teeth. We are committed to giving Mercedes the care she needs to heal, but we can’t do this without your help. The cost of this dental work and treatment is significant, but Mercedes deserves a chance to live a pain-free life. Your support can make all the difference for Mercedes. Every donation will help us provide her with the necessary surgeries and post-care she requires. Together, we can ease her suffering and help her regain the strength and comfort she so desperately needs. Thank you for opening your heart to Mercedes and for being a part of her healing journey!

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In a growing trend among celebrities, the diabetes medication Ozempic, along with its counterparts Wegovy, Mounjaro, and Zepbound, has sparked significant discussion regarding its use for weight loss. This surge in popularity has raised concerns among health professionals about the implications for individuals who may not need these medications for medical reasons. Dr. Caroline Apovian of Brigham and Women's Hospital emphasizes that these drugs are often sought after by those who are not necessarily facing obesity-related health risks. Celebrities like Lizzo, Rosie O'Donnell, and Eric Stonestreet have shared their experiences with these medications, highlighting both their benefits and drawbacks. Lizzo stated on a podcast that while she has tried Ozempic, she prefers managing her health through dietary discipline. Rosie O'Donnell showcased her weight loss journey on Instagram, attributing her success to using Mounjaro while managing diabetes. Notably, Meghan Trainor expressed gratitude for the support of Mounjaro following her second pregnancy, while Josh Gad referred to GLP-1 drugs as life-changing, helping him manage hunger. However, others like James Corden and Kandi Burruss have criticized the drugs, sharing personal anecdotes of their ineffectiveness. The conversation extends to notable figures like Oprah Winfrey, who has embraced weight loss medications as a tool for health management, and celebrities like Bella Thorne and Ice Spice, who have expressed skepticism about the societal pressures associated with these drugs. Amid this dialogue, concerns about body image and societal expectations remain prevalent. Many stars, including Jamie-Lynn Sigler and Rebel Wilson, have remarked on the pressure to conform to a certain standard of beauty, often exacerbated by the visibility of weight loss drugs in Hollywood. As demand for Ozempic and similar medications escalates, health experts caution against their misuse, urging individuals to consult medical professionals before starting any weight loss regimen. The ongoing discourse reflects a complex interplay of health, celebrity culture, and societal norms regarding body image and wellness.

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Kris Dayanti dan Ashanty memiliki perbedaan dalam menyikapi program diet yang ditekuni anak mereka, Aurel Hermansyah. Seperti diketahui, Aurel Hermansyah menekuni program diet selepas melahirkan anak keduanya pada 11 November 2023. perbandingan reaksi Ashanty dan Kris Dayanti menanggapi keputusan Aurel Hermansyah untuk berdiet. Lewat akun Instagram pribadinya baru-baru ini, Kris Dayanti sempat mengapresiasi perjuangan diet Aurel Hermansyah sehingga sukses mendapat badan ideal. Oleh karena itu, istri Raul Lemos tersebut meminta Aurel Hermansyah untuk segera mengakhiri program dietnya. Dia juga meminta sang anak untuk makan bersih. Ashanty sempat mengutarakan ekspresi keberatan dengan rencana anak sambungnya untuk berdiet. Hal itu diutarakannya ketika Atta Halilintar melarang Aurel Hermansyah berdiet. Ashanty menilai Aurel Hermansyah harus memenuhi kebutuhan asupan gizi harian agar lancar memberi ASI kepada anak bungsunya. ‎Ikuti saluran Tribun Pontianak di WhatsApp: https://whatsapp.com/channel/0029VaLdWgm9WtBzrkP5OS1K Download aplikasi berita TribunX di Play Store atau App Store untuk dapatkan pengalaman baru Kumpulan video menarik seputar dunia selebriti, gaya hidup dan sport style terkini untuk Anda. #krisdayanti #kd #raullemos #anaktiri #Athalia #ananghermansyah #aurelhermansyah #lawas #jadul #musisi #diva #awetmuda #damai #musuhan #konflik #mantan #foto #jadul #flawless #makeup #natural #riasan #shorts #beritaartis #beritaartisterbaruhariinidiindonesia #beritaartishariini #beritaartisindonesia #beritaartisterkiniindonesia #hotseleb #gosip #gosipceria #gosipartisindonesiahariiniyangterbaru #MataLokalMenjangkauIndonesia Program: - Host: - Editor Video: kia Uploader: - Simak berita selengkapnya di http://pontianak.tribunnews.com/ Simak Video Viral lainnya https://pontianak.tribunnews.com/topic/berita-video Follow us: Instagram: https://www.instagram.com/tribunsingkawangofficial/ Facebook: https://www.facebook.com/tribunsingkawangupdate Twitter: https://twitter.com/tribunpontianak TikTok: https://www.tiktok.com/@tribunsingkawang Terima Kasih Telah Subscribe, Like, dan comment konten-konten menarik dari Kami.

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Let me tell you about my favorite online telehealth company, CosmeticRx, they sell GLP-1 weight loss products to help you lose 15% of your body weight. This company is super popular nationally because they have the guaranteed lowest price in the US and with my code KEMUNTOBEAR you can get $100 off and try semaglutide for just $199.https://www.cosmeticrx.com/weight-loss-landing They are also the largest seller of Retin-A in the US, you can use my promo code to get Retin-A, Altreno, and Renova for $39, Latisse for $114 and a 3-month supply of anxiety depression medication for $69.” #cosmeticrx It takes two minutes to answer some medical questions, board-certified physicians will review your order and you get 2-day shipping. There are no charges beyond this flat fee, no matter the dosage. Price includes everything including follow-ups / check-ins to monitor your progress and free shipping. This price is ridiculous, use my code!

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In this video you're gonna learn how to lose belly fat by sleeping more based on the latest research. ►If you found this video helpful hit Subscribe to support the channel and share the video with your friends to spread the word◄ Key points: 1 - Sleeping More While in a Caloric Deficit Allows You To Burn More Fat And Keep More Muscle Study University of Chicago https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951287/ Study compared 8.5-hours-in-bed phase vs In the 5.5-hour phase Cutting back on sleep to 5.5 hours reduced fat loss by 55 percent. The number of calories they consumed was about ~1450 per day. Lost an average of 6.6 pounds during each 14-day session. During weeks with enough sleep, they lost 3.1 pounds of fat and 3.3 pounds of lean body mass. During the 5 hour sleep weeks participants lost an average of 1.3 pounds of fat and 5.3 pounds of fat-free mass. Lesson: While in a caloric deficit a sufficient amount of sleep helps you retain more muscle mass and lose more fat. 2 - Sleeping More Will Help You Be Less Hungry The same University of Chicago study checked ghrelin levels. During those weeks of 5.5 hours in bed the ghrelin levels of participants rose from 75 ng/L to 84 ng/L. Ghrelin is a hormone that increases appetite, and also plays a role in body weight. A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. https://www.ncbi.nlm.nih.gov/pubmed/18564298 Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535701/ Higher ghrelin levels have been shown to reduce energy expenditure, stimulate hunger and food intake, promote retention of fat and increase hepatic glucose production to support the availability of fuel to glucose dependent tissues. Research study https://press.endocrine.org/doi/abs/10.1210/jc.2004-1003 found that sleeping less than 6 hours triggers the area of your brain that increases your need for food while also depressing leptin (satiety hormone) and stimulating ghrelin (hunger hormone). 3 - Lack of Sleep Reduces Your Self-Control and Willpower to Fight Off Cravings Study published in Nature Communications found that a single night of sleep deprivation can impair activity in your frontal lobe, which controls complex decision-making. https://www.nature.com/ncomms/2013/130806/ncomms3259/full/ncomms3259.html Additionally lack of sleep increases your cortisol levels. And that also activates reward centers in your brain that make you crave food A combination of high ghrelin and cortisol shut down the areas of your brain that leave you feeling satisfied after a meal, meaning you feel hungry all the time, even if you just ate a big meal. Additionally Lack of sleep diminishes mental clarity to make good complex decisions, specifically with regards to the foods you eat—or foods you want to avoid. When we get tired we have increased activity in the amygdala, the reward region of your brain. This is one of the reasons why sleep deprivation destroys all adherence to a diet. It makes you crave very high-calorie foods. When rested you can greatly fight off this desire, but because your insular cortex (another portion of your brain) is weakened due to sleep deprivation, you have trouble fighting the urge and are more likely to indulge in all the wrong foods. Lastly a research published in Psychoneuroendocrinology found that sleep deprivation makes you select greater portion sizes of all foods, further increasing the likelihood of weight gain. https://www.sciencedirect.com/science/article/pii/S0306453013000176 4 - Sleep Sabotages Your Gym Time Scientists from Brazil in 2011(https://www.ncbi.nlm.nih.gov/pubmed/21550729) found that sleep debt decreases protein synthesis which causes muscle loss. Lack of sleep makes it harder for your body to recover from exercise by slowing down the production of growth hormone which is your natural source of anti-aging and fat burning that also facilitates recovery. The already reduced production of growth hormone due to lack of slow wave sleep is further reduced by more cortisol in your system. It's a very bad cycle with 1 simple solution: Get more sleep. As usual post your questions in the comments below! Talk soon, Mario For more check out: Facebook: https://www.facebook.com/MarioTomicOfficial Instagram: https://instagram.com/mariotomich Website: https://www.tomic.com Music used: DEAF KEV - Invincible https://www.youtube.com/watch?v=J2X5mJ3HDYE Facebook https://www.facebook.com/officialDEAFKEV YouTube https://www.youtube.com/user/ATMDubstep

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Ikaria Juice (MY FEEDBACK!) Ikaria Juice Review - Ikaria Juice Reviews #IkariaLeanBellyJuiceReview ##IkariaLeanBellyJuice ✅Official Website: 👉https://theikariajuice.com/?hopId=b8885c24-c7c9-4308-bd69-a4269ae8fe0a&&traffic_source=review ______________________________________________________________________ ❤️👉 • ⛔⛔Ikaria Juice (( MY FEEDBACK!! )) Ik... ______________________________________________________________________ Ikaria Lean Belly Juice – Is It Worth It? Discover the Benefits and Effects! What Is Ikaria Lean Belly Juice and What Is It Used For? Ikaria Lean Belly Juice is a natural supplement designed to support weight loss, boost daily energy levels, and improve digestion. It is suitable for both diabetics and non-diabetics, as it contains ingredients that help regulate blood sugar levels. If you’re looking for a safe and natural way to slim down and enhance your metabolic health, this product might be a great option. What Are the Ingredients, and Do They Really Work? Yes! Ikaria Lean Belly Juice is formulated with natural ingredients, backed by scientific research. One of its key components is Milk Thistle, known for its liver detoxification properties. A 2020 clinical study found that this plant can significantly reduce liver-related complications in individuals with fatty liver disease. This happens because Milk Thistle contains silymarin, a powerful antioxidant that fights free radicals and promotes toxin elimination. Does Ikaria Lean Belly Juice Have Any Side Effects? According to the manufacturer, Ikaria Lean Belly Juice is made with only natural and safe ingredients, with no known adverse effects. However, if you have pre-existing medical conditions or take medications, it's always best to consult a healthcare professional before starting any supplement. Where Is Ikaria Lean Belly Juice Manufactured, and Is It a Reliable Product? This supplement is made in the United States, in an FDA-registered facility, following strict Good Manufacturing Practices (GMP). This ensures the quality and safety of the ingredients used in the product. How to Improve the Absorption of Ikaria Lean Belly Juice’s Nutrients? Bioavailability refers to how well the body absorbs and utilizes nutrients from a food or supplement. To maximize the benefits of Ikaria Lean Belly Juice, it is recommended to take it on an empty stomach or with healthy fats like avocado, olive oil, and nuts, which enhance the absorption of its bioactive compounds. Did You Enjoy This Content? Support Our Channel! If you found this information helpful and want more videos about weight loss, natural health, and nutrition, leave a thumbs up 👍 and click the "Super Thanks" button to support our work! This helps us continue bringing science-based content to help you live a healthier life. Thank you! 😊 Tags Ikaria Lean Belly Juice Review Ikaria Lean Belly Juice Ikaria Lean Belly Juice Reviews Ikaria Lean Belly Juice Ingredients Ikaria Lean Belly Juice Side Effects Ikaria Lean Belly Juice Benefits Ikaria Lean Belly Juice Scam Ikaria Lean Belly Juice Results Ikaria Lean Belly Juice Supplement Ikaria Lean Belly Juice Honest Review

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💊 Ozempic for Weight Loss & Diabetes – The TRUTH! Risks, Side Effects & How It Works! 🚨 Should You Take Ozempic for Weight Loss? 🚨 Ozempic (semaglutide) is a popular medication for diabetes & weight loss, but is it safe? In this video, we break down how Ozempic works, its benefits, side effects, hidden risks, and who should take it. 💊 ⚠️ Before trying Ozempic, watch this to learn the truth! Don't fall for the hype—know the risks & alternatives! 📢 Drop a comment: Are you considering Ozempic, or have you tried it? Share your thoughts below! 🔔 Subscribe for expert health advice! #ozempic #weightloss #diabetes #ozempicweightloss #health #fitness #weightlosstips #healthylifestyle #pharmacist #weightlossjourney #fatloss #diabetesmanagement A Must-Watch Guide on Ozempic! Is This Viral Weight Loss Drug Safe or Dangerous? The Truth About Ozempic for Weight Loss & Diabetes – How It Works, Side Effects, Hidden Risks, and Who Should Take It! Doctors & Celebrities Swear By It, But Should You? Don’t Take Ozempic Before Watching This! Real Facts, No Hype – Everything You Need to Know Before Using This Medication! Stay Safe & Informed! "Ozempic for Weight Loss: Shocking Truth, Benefits, Side Effects & Who Should Take It – A Pharmacist Explains Everything You Need to Know Before Using This Diabetes Drug for Fat Loss!

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20 minutes of staying at 70% your heart rate maximum (your fat burning zone)! Listen to the beats of this workout or play your own as you follow the exercises I am doing to keep your heart rate up, burn calories and boost your metabolism. This workout is an easy go-to for your morning rush. If this is your first time working out with me, know that this is a place where we normalize enjoying your workouts so that it becomes something you can come back to daily. Women across the world have lost, 20, 50, 100, even 150lbs doing these workouts and I know that you too will see sustainable results when you get consistent with these workouts. If you are ready to be committed, leave a comment that shares when you're starting and how many days a week you are committing to moving your body with me. Enjoy more weekly workout releases in the GWJ home App: https://growwithjo.com _______ GENERAL INQUIRY EMAIL → [email protected] PARTNERSHIPS EMAIL → [email protected] _______ DISCLAIMER: All information provided by growwithjo is of a general nature and is furnished only for educational/entertainment purposes only. No information is to be taken as medical or other health advice pertaining to any individual specific health or medical condition. You agree that use of this information is at your own risk and hold growwithjo harmless from any and all losses, liabilities, injuries or damages resulting from any and all claims.

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Nagano Tonic is your new go-to for natural weight loss Are you tired of struggling with weight loss and looking for a natural solution that actually works? Meet Nagano Tonic, the revolutionary formula designed to support healthy weight management while boosting your overall well-being. Inspired by traditional Japanese health practices, this powerful tonic is packed with natural ingredients that help enhance metabolism, curb cravings, and promote sustainable fat loss. Why choose Nagano Tonic? - **100% Natural Ingredients**: Crafted with a unique blend of herbs and plant-based extracts known for their weight loss benefits. - **Boosts Metabolism**: Helps your body burn fat more efficiently while maintaining energy levels. - **Reduces Cravings**: Supports appetite control to prevent overeating and unnecessary snacking. - **Improves Digestion**: Aids in gut health, ensuring better absorption of essential nutrients. - **Easy to Use**: Just a simple daily dose can help you stay on track with your weight loss goals. Unlike other weight loss supplements filled with artificial chemicals and harmful additives, Nagano Tonic is formulated with nature’s best ingredients to ensure safe and effective results. Whether you’re looking to shed a few pounds or kickstart a complete health transformation, this tonic is here to help you achieve your goals naturally. Thousands of users have already experienced the benefits of Nagano Tonic. Don’t miss out on this game-changing formula that could finally help you achieve the body you’ve always wanted. Ready to take control of your weight loss journey? Click the link in the first comment to get your bottle today and start seeing real results. Disclosure: This video contains affiliate links. If you click on one of these links and make a purchase, I may receive a small commission at no extra cost to you. These commissions help support the channel and allow me to continue creating content like this. Thank you for your support!

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In this episode of The NSJD Show (Ep. 54), we dive deep into the truth behind the popular keto diet. Does keto really work for weight loss? Is it effective, or just another trendy fad? In this video, I break down the science of the keto diet, debunk common keto myths, and discuss why it might not be the best choice for everyone. We'll cover: ✅What keto dieting is and how it works ✅ The origins of the keto diet ✅ The pros and cons of the keto diet ✅ My personal take on whether keto is really effective for long-term fat loss ✅ Why keto might not be suitable for some people And much more! Whether you're thinking about starting keto or just want to know more, this video will give you all the facts you need to make an informed decision. Join our Facebook community: https://www.facebook.com/groups/903280784210493 Instagram: https://www.instagram.com/nsjd_1 Facebook page: https://www.facebook.com/NSJDofficial Tik Tok: noroze_nsjd #KetoDiet #KetoScam #fatlosstips #KetoScam ✅ #KetoMyths ✅ #KetoDebunked ✅ #CICO (Calories In, Calories Out) ✅ #FitnessScience #WeightLossJourney ✅ #FatLossTips ✅ #FitnessPodcast ✅ #BodybuildingLifestyle ✅ #HealthMyths #DesiFitness ✅ #PakistaniFitness ✅ #IndianFitness ✅ #WeightLossPakistan ✅ #KetoIndia

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GLP-1 Drugs: My Weight Loss Breakthrough! 💪🔥 Struggling with weight loss? You're not alone! In this video, I share my personal journey using GLP-1 drugs and how they have transformed my approach to health and wellness. 🚀 From overcoming plateaus to experiencing real, sustainable results, I'll walk you through my progress, challenges, and key takeaways. 💡 What You’ll Learn: ✅ What GLP-1 drugs are and how they work 🧐 ✅ My before & after weight loss experience 📉 ✅ The benefits & side effects you should know ⚠️ ✅ Tips for maximizing results and staying healthy 🌱 ✅ Is this the right approach for YOU? 🤔 Losing weight isn’t just about a quick fix—it’s about creating a lifestyle that lasts! If you’re curious about GLP-1 medications and whether they can help you on your journey, this video is for you! 🎯 💬 Have you tried GLP-1 medications or another weight loss strategy? Drop your experience in the comments! 👇 🔔 Don't forget to LIKE, SHARE & SUBSCRIBE for more health & wellness insights! 🌟 MC introduces Beatriz Fritschler, an astonishing creator of Executive Losers! Beatriz shares her story of overcoming an aneurysm and her powerful journey to regain her health and well-being. Her story inspires us all as we journey toward a healthier and more glorious body and mind. Beatriz Fritschler is a social impact strategist, author, and wellness entrepreneur who has transformed personal adversity into purpose-driven leadership. After surviving a life-altering brain aneurysm, she chronicled her journey of resilience and self-reclamation in her memoir Embody Joy: A Woman’s Journey of Reconnection with Her Body. As the founder of Executive Losers, a wellness community for high-achieving women, she empowers professionals to achieve sustainable health and vitality. Beatriz’s career spans philanthropy, nonprofit leadership, and public-private partnerships, driving initiatives that uplift vulnerable communities. A certified Personal Trainer and Nutrition Coach (ISSA) and Lifestyle & Wellness Coach (Harvard), she embraces her current life as an athlete, proving that strength, joy, and success are deeply embodied experiences. Beatriz Fritschler Founder & Chief Executive Officer Author of Embody Joy: A Woman’s Journey of Reconnection with Her Body Website: www.ExecutiveLosers.com LinkedIn: https://www.linkedin.com/company/executive-losers Instagram: https://www.instagram.com/executive_losers/ Facebook: https://www.facebook.com/ExecutiveLosers YouTube: https://www.youtube.com/@ExecutiveLosers Be well, my friends. We have this one precious life; let's live it intentionally. 🌿💚 📌 Disclaimer: The views shared here are solely for education and entertainment. They are not endorsed by my employer or any affiliated companies. This content reflects personal perspectives, and I encourage everyone to consult with healthcare professionals for medical advice. Check out MC at www.marycatherinegeorge.com =================================== Watch my More videos 🔰 Catalina Snack Mix Keto Review: Must-Watch! 🎬 https://www.youtube.com/watch?v=mziLKhfubKU 🔰 Boost Your Mood with Essential Oils 🎬 https://www.youtube.com/watch?v=bjTgip4tO5c 🔰 Why choose Organic Foods - Pesticides are related to Cancer 🎬 https://www.youtube.com/watch?v=QH_tcFzXAdQ ============================ ⏰ Video Duration: 00:00:28 https://www.youtube.com/shorts/pz4wjM6-e14 ========================== Follow us on Social Media: Youtube : https://www.youtube.com/@healthybygeorge3425/videos 🔥INSTAGRAM: https://www.instagram.com/healthybygeorge6/ 💎WEBSITE: https://www.marycatherinegeorge.com/ 🔮FACEBOOK: https://www.facebook.com/profile.php?id=100071895693054 📧 For Business Inquiries 📧 Mail: [email protected] ⚠️ hashtags⚠️ #glp1drugs , #weightlossjourney, #healthtransformation, #weightlosstransformation, #wellnessjourney, #glp1medication, #weightlossmotivation, #healthbreakthrough, #healthyweightloss, #weightlossprogress, #slimmingdown, #fitnesstransformation, #healthandwellness, #weightlosstips, #bodytransformation, #weightlosstruth, #fitnesstips, #wellnessgoals, #weightlosshelp, #losingweightnaturally, #glp1weightloss, #healthyhabits, #lifestylechange, #weightlossresults, #weightlossjourney2025, #fitgoals, #healthsuccess, #slimdownjourney, #healthylifestyle, #transformationjourney

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Semaglutide is an exciting new drug that has been gaining attention for its potential to aid in weight loss. Approved by the FDA for weight management in adults with obesity or overweight, semaglutide works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1). This hormone helps regulate blood sugar levels, but it also plays a role in appetite control and weight management. Understanding how semaglutide works can help us appreciate its potential benefits for those struggling with weight issues.

Signaling Pathways Activation

One of the key mechanisms of action of semaglutide is the activation of certain signaling pathways in the body. When semaglutide binds to GLP-1 receptors in the brain, it triggers a cascade of events that result in reduced appetite and increased feelings of fullness. This can lead to reduced food intake and ultimately, weight loss. By targeting specific pathways related to appetite regulation, semaglutide offers a targeted approach to weight management.

Slowing Gastric Emptying

Another way semaglutide helps with weight loss is by slowing down the rate at which food moves through the stomach. This delay in gastric emptying can help control blood sugar levels and reduce spikes in insulin, which are common in people with obesity or diabetes. By slowing gastric emptying, semaglutide can help regulate appetite and food intake, leading to gradual weight loss over time.

Impact on Energy Expenditure

Semaglutide has also been shown to have an impact on energy expenditure, or the number of calories the body burns at rest. Studies have suggested that semaglutide may increase energy expenditure, helping individuals burn more calories even when they are not active. This can further contribute to weight loss by creating a calorie deficit, where the body burns more calories than it consumes.

Improvement in Insulin Sensitivity

Insulin sensitivity plays a crucial role in weight management and overall metabolic health. Semaglutide has been found to improve insulin sensitivity in individuals with obesity or diabetes, leading to better blood sugar control and reduced risk of weight gain. By enhancing insulin sensitivity, semaglutide can help the body utilize glucose more effectively and prevent excess fat storage, ultimately supporting weight loss goals.

Long-Term Effects on Weight Maintenance

Research has shown that semaglutide can have long-term effects on weight maintenance, even after the drug is discontinued. This sustained weight loss may be due to the lasting changes in appetite regulation, energy expenditure, and metabolic function that semaglutide helps facilitate. By addressing multiple aspects of weight management, semaglutide offers a comprehensive approach to achieving and maintaining a healthy weight in the long run.

In conclusion, the mechanism of action of semaglutide for weight loss involves targeting specific pathways related to appetite regulation, gastric emptying, energy expenditure, and insulin sensitivity. By understanding how semaglutide works at a molecular level, we can appreciate its potential to help individuals struggling with weight issues achieve their goals in a safe and effective manner.

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