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Last updated on 2025-11-18

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I do weekly Live Chit Chat sessions and love making some highlight videos afterwards! 💉✨ In this video, I talk about how it's normal to be hungry on a GLP1 Medication. Please Note: RESULTS MAY VARY 🎥 Why Watch This Recap? Expert insights and firsthand experiences Learn how GLP-1 meds can fit into a healthy lifestyle Tips for diet and exercise while on GLP-1 meds 📝 Resources Mentioned in the Video: Looking for a telehealth provider? www.elliemd.com/glp1bestie 📅 Stay Connected! Subscribe and hit the bell icon to stay updated with my latest content on GLP-1 medications, healthy recipes, fitness tips, and more. Join the GLP1 Bestie community and take control of your health journey! 👍 Like, Share, and Comment! If you find this video helpful, please give it a thumbs up, share it with your friends, and leave your questions and thoughts in the comments below.

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Oral GLP-1 agonists—like oral semaglutide—are poised to transform the future of obesity and type 2 diabetes treatment. But how close are we to seeing these medications approved and widely available? In this video, we explore the following: How close are we to oral GLP-1s? Will we ever see ozempic and mounjaro tablets? If so, when? Will Eli Lilly, Novo Nordisk or someone else be first to market? Links: Pfizer’s press release discontinuing research on their candidate molecule: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-oral-glp-1-receptor-agonist Eli Lilly’s April press release on Orfoglipron https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically#:~:text=News%20Release-,Lilly's%20oral%20GLP%2D1%2C%20orforglipron%2C%20demonstrated%20statistically%20significant%20efficacy,orforglipron%20worldwide%20without%20supply%20constraints. And their follow-up press release on having these results prublished in the New England Journal of Medicine: https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-showed-compelling-efficacy-and#:~:text=Lilly's%20oral%20GLP%2D1%2C%20orforglipron,Medicine%20%7C%20Eli%20Lilly%20and%20Company NovoNordisk’s progress as of May 2025: https://www.reuters.com/sustainability/boards-policy-regulation/us-fda-accepts-novo-nordisks-application-oral-wegovy-2025-05-02/ Animal study linking *liraglutide* with thyroid cancer, suggesting it may be species-specific https://academic.oup.com/endo/article-abstract/151/4/1473/2456651?redirectedFrom=fulltext&login=false Timestamps: Timeline for getting a new drug to market [00:28] Who is developing oral GLP-1 agonists? [01:22] Eli Lilly - Orforglipron [02:22] Novo Nordisk - Rybelsus (semaglutide) and NN-9932 [04:42] What else is brewing (“The best of the rest”) [06:11] Okay, so you’ve hear a little something about ozempic, wegovy and the gang, a group of utterly revolutionary large molecules that can help aid in really significant weight loss through a series of injections helping to curb appetite and slow gastric emptying, making you feel fuller for longer, wouldn’t it be neat if this came as a tablet? Eli Lilly and Novo Nordisk think so. Eli Lilly, producer of Mounjaro and Zepbound has one drug in Phase III trials, orforglipron, with results coming out from last month and expected to keep rolling in for the rest of the year and the start of next. After which, we may see it launched as an oral medication for both diabetes and weight loss Novonordisk, already has an oral medication FDA approved but only for the management of diabetes, Rybelsus Eli Lilly have over 6,000 people enrolled in ACHIEVE phase 3 trial that is investigating orforglipron as a diabetes medicine and intend to publish the rest of the data in late 2025 and 2026. They are also running their phase 3 trials investigating its efficacy as a weight management drug under the name ATTAIN and expect to submit to the FDA and other global regulatory bodies before the end of 2025, meaning that if the trials continue to come in with positive results and the FDA are happy, Eli Lilly will be bringing an oral weight loss drug to market around the middle of 2026. as for Novo, they’ve been a lot quieter with their press releases of late Rybelsus, its an oral formulation of Novo Nordisk’s semaglutide molecule, which has proven itself effective time and time again in injection form under brands, Ozempic and Wegovy. Its already out there in the US and Europe and works, though the weight loss effects appear to be about half that of Wegovy. clinical studies have found that increasing the dose increases the weight loss achieved, with one 68-week study finding a 50mg daily oral dose led to 15% weight loss, again, linked down below. the best of the rest: On April 14, Pfizer announced the termination of the development of an attempt at an oral obesity medication after the molecule, named danuglipron, was found to damage the livers of a participant of a phase 2 trial. HRS9531, published their phase 2 trial outcomes in June 2024, finding that, in a study of 249 patients a 6.0mg INJECTION lead to an average weightloss of 16% in just 26 weeks in obese, non-diabetic participants. The phase two trial is linked down below https://diabetesjournals.org/diabetes/article/73/Supplement_1/1861-LB/155203/1861-LB-Efficacy-and-Safety-of-HRS9531-a-Novel Both Eli Lilly and Novo Nordisk are near the final hurdle, so, oral weight loss medications of the GLP-1 agonists may be arrive early 2026. ** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **

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Explore our entire animation video library at: https://www.nonstopneuron.com/ All videos from endocrine pharmacology: https://www.nonstopneuron.com/post/pharmacology-endocrine-system Video Summary: GLP-1 receptor agonists are basically GLP-1 analogs resistant to degradation by DPP-4. They directly stimulate the GLP-1 receptor and cause insulin release. DPP-4 inhibitors, on the other hand, prevent the degradation of endogenous GLP-1. So the effect of GLP-1 on β cells is increased and again, more insulin is released ● More videos on Insulin and Diabetes • Mechanism of Insulin Secretion: https://youtu.be/5M7Lj9Fx1_w • Mechanism of Action of Sulfonylureas and Meglitinide Analogues: https://youtu.be/rz7KJK_EMpA • Oral Antidiabetic Drugs Classification: https://youtu.be/mMRQiaxkyCM ● Follow me at: • Facebook: https://www.facebook.com/NonstopNeuron • Instagram: https://www.instagram.com/NonstopNeuron/ DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

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Xtreme Change Keto Gummies have taken the health and wellness world by storm with their promising benefits for weight loss and overall well-being. These gummies are a convenient and tasty way to incorporate the benefits of ketosis into your daily routine. But what exactly are Xtreme Change Keto Gummies, and how do they work?

Understanding Xtreme Change Keto Gummies

Xtreme Change Keto Gummies are a dietary supplement that aims to support ketosis in the body. Ketosis is a metabolic state where the body burns fat for fuel instead of carbohydrates, leading to weight loss and increased energy levels. These gummies are formulated with ketones, which are the molecules produced during ketosis. By consuming Xtreme Change Keto Gummies, you can potentially accelerate the process of ketosis and experience its benefits more quickly.

Xtreme Change Keto Gummies are made with natural ingredients, making them a safe and effective option for those looking to boost their ketosis journey. The gummies are easy to incorporate into your daily routine, whether you’re at home, work, or on the go. With their delicious flavors and convenient form, Xtreme Change Keto Gummies make it easier than ever to stick to your ketogenic diet and achieve your weight loss goals.

The Science Behind Xtreme Change Keto Gummies

The key ingredient in Xtreme Change Keto Gummies is beta-hydroxybutyrate (BHB), a type of exogenous ketone that can help kickstart ketosis in the body. When you consume BHB, it is broken down into ketones that are used as a source of energy by the body. This can lead to increased fat burning, improved mental clarity, and enhanced physical performance. By taking Xtreme Change Keto Gummies regularly, you may be able to maintain a state of ketosis more easily and see faster results.

In addition to BHB, Xtreme Change Keto Gummies are also fortified with other vitamins and minerals that support overall health and well-being. These nutrients can help fill any gaps in your diet and ensure that your body has everything it needs to function at its best. With Xtreme Change Keto Gummies, you can support your ketogenic lifestyle and feel confident that you’re giving your body the fuel it needs to thrive.

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There are numerous potential benefits to incorporating Xtreme Change Keto Gummies into your daily routine. Some of the most common advantages reported by users include faster weight loss, increased energy levels, and improved mental clarity. By supporting ketosis in the body, these gummies can help you reach your weight loss goals more quickly and feel better overall.Glp1 What You Need To Know About Weight Loss Drugs Weightloss

Other potential benefits of Xtreme Change Keto Gummies include reduced cravings for unhealthy foods, better digestion, and enhanced athletic performance. By providing your body with the nutrients it needs to thrive, these gummies can help you look and feel your best. Whether you’re new to the ketogenic diet or a seasoned pro, Xtreme Change Keto Gummies can be a valuable addition to your wellness routine.

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For best results, it is recommended to take Xtreme Change Keto Gummies daily as part of a healthy diet and exercise plan. Each bottle of gummies contains a 30-day supply, making it easy to stay on track with your ketosis goals. Simply consume the recommended dosage of gummies each day, either on their own or as part of a meal or snack.

It’s important to remember that Xtreme Change Keto Gummies are a supplement and should not be used as a substitute for a balanced diet. While these gummies can support ketosis in the body, they work best when combined with a healthy lifestyle. Be sure to drink plenty of water, get regular exercise, and eat a variety of nutritious foods to maximize the benefits of Xtreme Change Keto Gummies.

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Obesity specialist Dr Holly Lofton reveals how she chooses the right GLP-1 for each patient, and the importance of staying on label. https://www.medscape.com/viewarticle/1000524?src=soc_yt -- TRANSCRIPT -- Hi. I'm Dr Holly Lofton. I'm a board-certified obesity medicine specialist, and I direct the medical weight management program at NYU Langone Health. With all the excitement about GLP-1 agonists, I get many questions from providers about which antiobesity drug they should prescribe. I'll tell you the methods that I use to determine which drug is best for which patient. Of course, we want to make sure that we're treating the right condition. If the patient has type 2 diabetes, we tend to give them medication that is indicated for type 2 diabetes. Many GLP-1 agonists are available in a diabetes version and a chronic weight management or obesity version. If a patient has diabetes and obesity, they can receive either one. If a patient has only diabetes but not obesity, they should be prescribed the diabetes version. For obesity without diabetes, we tend to stick with the drugs that are indicated for chronic weight management. Let's go through them. Exenatide. In chronological order of approval, the first GLP-1 drug that was used for diabetes dates back to exenatide (Bydureon). Bydureon had a partner called Byetta (also exenatide), both of which are still on the market but infrequently used. Some patients reported that these medications were inconvenient because they required twice-daily injections and caused painful injection-site nodules. Diabetes drugs in more common use include liraglutide (Victoza) for type 2 diabetes. It is a daily injection and has various doses. We always start low and increase with tolerance and desired effect for A1c. Liraglutide. Victoza has an antiobesity counterpart called Saxenda. The Saxenda pen looks very similar to the Victoza pen. It is a daily GLP-1 agonist for chronic weight management. The SCALE trial demonstrated 8%-12% weight loss with Saxenda. Those are the daily injections: Victoza for diabetes and Saxenda for weight loss. Our patients are very excited about the advent of weekly injections for diabetes and weight management. Ozempic is very popular. It is a weekly GLP-1 agonist for type 2 diabetes. Many patients come in asking for Ozempic, and we must make sure that we're moving them in the right direction depending on their condition. Semaglutide. Ozempic has a few different doses. It is a weekly injection and has been found to be quite efficacious for treating diabetes. The drug's weight loss counterpart is called Wegovy, which comes in a different pen. Both forms contain the compound semaglutide. While all of these GLP-1 agonists are indicated to treat type 2 diabetes or for weight management, Wegovy has a special indication that none of the others have. In March 2024, Wegovy acquired an indication to decrease cardiac risk in those with a BMI ≥ 27 and a previous cardiac history. This will really change the accessibility of this medication because patients with heart conditions who are on Medicare are expected to have access to Wegovy. Tirzepatide. Another weekly injection for treatment of type 2 diabetes is called Mounjaro. Its counterpart for weight management is called Zepbound, which was found to have about 20.9% weight loss over 72 weeks. These medications have similar side effects in differing degrees, but the most-often reported are nausea, stool changes, abdominal pain, and reflux. There are some other potential side effects; I recommend that you read the individual prescribing information available for each drug to have more clarity about that. It is important that we stay on label for using the GLP-1 receptor agonists, for many reasons. One, it increases our patients' accessibility to the right medication for them, and we can also make sure that we're treating the patient with the right drug according to the clinical trials. When the clinical trials are done, the study populations demonstrate safety and efficacy for that population. But if we're prescribing a GLP-1 for a different population, it is considered off-label use. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/1000524?src=soc_yt

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The ketogenic diet has taken the health and wellness world by storm, with many people experiencing incredible weight loss and health benefits by following this high-fat, low-carb eating plan. However, sticking to a ketogenic diet can be challenging, especially when it comes to maintaining ketosis, the state where your body burns fat for fuel instead of carbohydrates. That’s where BHB comes in. BHB, or Beta-Hydroxybutyrate, is a ketone body that can help you achieve and maintain ketosis more easily, making it a game-changer for anyone following a ketogenic diet.

The Shark Tank Effect

One of the most popular ways BHB has gained widespread attention is through its appearance on the hit TV show Shark Tank. Entrepreneurs have pitched their BHB products to the sharks, hoping to secure funding and partnerships that will take their businesses to the next level. The exposure from appearing on Shark Tank has catapulted many BHB companies to success, bringing ketone body supplements into the mainstream and making them more accessible to people looking to enhance their ketogenic lifestyle.

When BHB products first hit the market, they were primarily targeted towards athletes and fitness enthusiasts looking to boost their performance and recover faster from workouts. However, as more research has emerged about the benefits of ketosis for overall health and weight loss, BHB supplements have gained popularity among a wider audience. People of all ages and fitness levels are now incorporating BHB into their daily routine to support their ketogenic diet and reap the rewards of increased energy, mental clarity, and fat burning.

The Science Behind BHB

But what exactly is BHB, and how does it work? Beta-Hydroxybutyrate is one of the three ketone bodies produced by the liver during fasting or when following a ketogenic diet. It is a more efficient fuel source for your body and brain compared to glucose, providing a steady supply of energy without the spikes and crashes associated with carb-heavy diets. By taking BHB supplements, you can increase your blood ketone levels, giving you a quick and convenient way to get into and stay in ketosis without strictly adhering to a strict diet.

In addition to promoting ketosis, BHB has been shown to have other health benefits as well. Studies have found that BHB can help reduce inflammation, improve insulin sensitivity, and support healthy weight management. By incorporating BHB into your daily routine, you can not only enhance your ketogenic experience but also improve your overall health and well-being. With all these benefits, it’s no wonder BHB has become a staple in the keto community and beyond.

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Choosing the Right BHB Product

With so many BHB products on the market, it can be overwhelming to decide which one is right for you. When choosing a BHB supplement, it’s important to look for a high-quality product that is made with pure, clean ingredients and free from artificial additives and fillers. You should also consider the form of BHB that best suits your needs, whether it’s in powder, capsule, or liquid form. Reading reviews and doing your research can help you find a reputable brand that delivers on its promises and helps you achieve your health and fitness goals.

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Najlepiej gubić wagę aktywnością fizyczną i dietą. To oczywiste. Droga na skróty to robiący w ostatnich latach agoniści GLP-1, leki przeciwcukrzycowe pozwalające na szybką redukcję wagi. Mają mnóstwo zalet, ale czy kryją też ciemną stronę?? Na to pytanie odpowiemy w kolejnym odcinku podcastu "W Stronę Długowieczności". Zapraszamy - prof. Marek Postuła i Krzysztof Łoniewski

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