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Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. *Guest information* Anurag Singh, MD, PhD Chief Medical Officer at Timeline *Thank you to our sponsor* Timeline: https://tinyurl.com/4npjcvjf Mitopure: https://tinyurl.com/ypfjws2e Research from Timeline: https://tinyurl.com/53p6yjc9 [email protected] *Timeline Discount for New Frontiers Listeners* Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout. *Show Notes* Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85 Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56 Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5 Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7 *DrKF Resources* FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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Gentle Patches GLP 1 Reviews: Does It Work Or Scam? Are Gentle Patches GLP-1 really the weight loss solution they claim to be? 🤔 In this video, we review the popular transdermal patches that say they boost GLP-1 naturally, curb cravings, and support your metabolism — all without pills or effort. But are they actually effective, or just another hyped-up product? Let’s find out! 💬⚠️ ⚠️ Red Flags to watch for: 🔴 Claims to support GLP-1 without containing any real GLP-1 medication 🔴 Extremely low ingredient doses that are unlikely to do anything 🔴 Transdermal delivery may not work for water-based nutrients 🔴 No clinical evidence or scientific proof 🔴 Marketing tricks with confusing pricing and false urgency We break it all down so you can make a smart decision before spending your money. 💵 Stay informed and protect yourself from gimmicky health trends. Tags: Gentle Patches, Gentle Patches review, Gentle GLP-1 patch, GLP-1 patch review, Gentle weight loss patch, Gentle Patches scam, Gentle Patches GLP 1 Reviews Copyright Disclaimer: - Under section 107 of the Copyright Act 1976, allowance is made for FAIR USE for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is permitted by copyright statutes that might otherwise be infringing. Non-profit, educational, or personal use tips the balance favor of FAIR USE.

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How to Do a Sumo Squat: 1. Setup: Stand with your feet wider than shoulder-width apart. Point your toes outward at about a 45-degree angle. Keep your chest upright and core engaged. 2. Execution: Lower your body by bending your knees and pushing your hips back as if sitting into a chair. Keep your knees aligned with your toes and avoid letting them cave inward. Lower until your thighs are parallel to the ground or as deep as your mobility allows. Push through your heels to return to the starting position, squeezing your glutes at the top. 3. Tips: Keep your back straight; avoid rounding or arching excessively. Use weights like dumbbells or kettlebells for added resistance, holding them in front of your chest or between your legs. Benefits of Sumo Squats: Strengthens Lower Body: Targets the quadriceps, hamstrings, glutes, and inner thighs. Improves Flexibility: Enhances mobility in the hips, which is great for daily activities and other exercises. Builds Core Stability: Engages the core muscles to maintain balance and posture. Tones Inner Thighs: The wide stance emphasizes the inner thighs, helping sculpt and strengthen them. Low-Impact Option: Suitable for people of various fitness levels as it’s easier on the knees compared to some other squat variations. Functional Fitness: Mimics movements used in daily life, improving overall functional strength. Versatile: Can be done with bodyweight, resistance bands, or weights, allowing for progression. fitness fit mom motivation workout yoga fat loss lower back hips booty glute belly fat tummy fat Sumo Squats weight loss yoga motivation belly fat hips workout leg fitness jiyansh chauhan gym songs cardio dance zumba sumo squats leg day workout home workout yoga flow leg day leg workout full body workout bikini body hip workouts zumba dance squat workout glute exercises home workout glute workout yoga for beginners knee surgery knee pain why is my knee swollen hip mobility mobility squats glute activation dumbbell leg workout full body #weightloss #song #diet #bellyfatloss

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On a new segment of The Exam Room podcast, host Chuck Carroll talks about his personal weight loss story with Dr. Neal Barnard. He lost an incredible 265 pounds—going from 420 pounds to just 155 pounds. He talks about his battle with food addiction, and Dr. Barnard explains the science of food addiction. Listen to the full episode: PCRM.org/Podcast.

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You've probably heard conflicting stories about GLP-1 drugs like Ozempic, Wegovy, Mounjaro, and Zepbound. Some say they're miracle drugs, while others argue they're just a temporary fix a Band-Aid masking deeper issues. But what's the real truth? As a triple board-certified endocrinologist and obesity specialist who has personally battled diabetes, I’m here to share the complete truth about GLP-1 medications and insulin resistance. These medications aren’t just sugar-lowering drugs; in the right context, they actually help undo insulin resistance at its root. Yes, GLP-1 drugs can help you eat less and lose weight, but it goes deeper. Recent studies show they help you naturally avoid ultra-processed foods packed with endocrine disruptors and toxins causing insulin resistance, inflammation, and obesity. By calming cravings, these drugs remove the "fuel" that's making you metabolically sick. But there’s a catch. If you’re not using GLP-1 medications correctly, maintaining protein intake, strength training, getting quality sleep, and managing stress, you may miss out on these powerful long-term benefits. And what about those scary headlines like "Ozempic Face"? I dive into that too, separating the facts from sensationalized fiction. So, do GLP-1 medications really fix insulin resistance, or are they just a temporary fix? And who should stay on them long-term? Join me as I unpack all these questions and provide clarity once and for all. Host: Dr. Yasmine Elamir Founder of the Type 2 Diabesity Transformation Method Triple Board Certified Obesity Specialist, Endocrinologist, and Internist YouTube Channel: https://youtube.com/@diabetes_MD?si=vBrsuapqtnmvkgk- Connect with me: Website: https://elamirwellness.com/ Email: [email protected] LinkedIn: https://www.linkedin.com/in/dr-yasmine-elamir-2337a514a/ Facebook: https://www.facebook.com/p/Dr-Yasmine-Elamir-100087940785418/ Instagram: https://www.instagram.com/diabetes_md/ X (formerly Twitter): https://x.com/ElamirWellness 00:00 Intro 00:30 Start 01:00 GLP-1s are not Just Sugar Lowering Drugs 05:26 Myths about GLP-1 | Ozempic Face & Muscle Loss 05:39 Ozempic Face 06:19 Muscle Loss 07:48 GOOD SLEEP, GOOD HYDRATION 09:00 Liver Fat Shrinking 09:22 Altering Gut Mobility 10:13 When Do You Stop Using GLP-1 and Who Should Stay for the Long Term 12:53 Conclusion 14:44 End #InsulinResistance #Ozempic #GLP1 #DiabetesLifestyle #weightloss #mounjaro #wegovy #zepbound https://apps.apple.com/ph/app/diabesity-reversal-method/id6741229316 Enjoy a 3-day free trial inside the Diabesity Reversal Method app.

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Make exercise something you LOVE to do, not something you punish yourself with. Get my *free* resources: Grab a free copy of my first #1 best selling book, Diet Disruption: https://www.diet-disruption.com/freecopy Grab a free copy of my 2nd #1 best selling Book, Stop Sabotaging Your Weight Loss: https://www.stopsabotagingyourweightlossbook.com/ Get free access to my Video Series to learn why you sabotage and how to fix it: https://www.jenniferpowter.com/videos I’m Jennifer Powter, a weight loss and fitness expert. I’m super excited about this video today. Why? Because it’s one of the things I hear women asking for all over the world, it’s something that I hear trainers promise that they can deliver, bootcamps guaranteeing that they will provide, and it’s really actually very difficult to achieve. What is it? It’s the age old question, “Can we build muscle and lose fat at the exact same time?” Let’s dive into muscle first. Let’s take a look at one pound of muscle right here. Let’s just pretend this is your bicep muscle. (It’s actually pork tenderloin.) To actually build muscle we’re asking our body to go into a catabolic state, meaning that we’re taking small units, building it and putting them together to create protein synthesis. That is how we make muscle. For instance, this muscle is beautiful right now as it is. If I want to make it bigger I have to eat more so I can add more bulk to the muscle. Here’s a pound of fat. Most of us have body fat on us. We need a certain amount of fat, it’s healthy, it’s how we make cholesterol, some fat is good for us. However, some of my clients come to me saying that they want to lose fat and build muscle. The thing is to lose fat we have to be a slight caloric deficit and to build muscle you have to be in a caloric positive state. So, to build muscle we have to eat more and to lose fat we have to eat less. How do we achieve both of those physiological states at the exact same time? For most of us – the average woman out there, people like me, people like you – it’s extremely difficult to accomplish. It’s often what puts us into “weight loss purgatory,” that state where you’re exercising a ton, your body composition isn’t changing, and your bootcamp instructor or your personal trainer is telling you, “Don’t worry, it’s because you’re building muscle and losing fat, your weight is just staying the same.” No, it’s not. You’re not achieving either goal and you’re staying stuck at the exact same thing. We have the nice bicep muscle and then we have this layer of fat over it. Now you think, “I want to look a bit more toned for summer. I want to have my arms looking nice in dresses or tank tops,” or whatever it is you have in your closet that you want to feel great and look sexy in. You think, “Great, I want to build muscle and lose some fat.” If you actually do the work and try to increase your muscle size without decreasing any of the fat, you’re still not going to see the tone. In fact, your arms are simply going to look bigger. That’s usually not the goal we’re going after. When we actually go after losing fat first, what we’re doing is putting our bodies into a catabolic process, a metabolic pathway where the fat cell is actually broken down and it’s released into smaller forms so it can turn into energy. What that actually ends up looking like on our body is slowly the layer of fat gets smaller. As that layer of fat gets smaller and we keep working on releasing it, because fat is just stored energy – that’s it, it’s energy that is waiting on our body that we can use and release to do more work – this is what it starts to look like. Don’t worry about hitting the gym and hitting the weights super hard. Definitely worry about being active and having fun and working out, but the easiest thing for you is to simply eat just a little bit less so you can take these stored energy pockets on your body and utilize them and mobilize that fat as fuel. Make sense? Good. Thanks so much for watching. I’ll be back again soon with another video for you. Happy biceps.

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Today's video contains exercises for kids combined in a home workout designed to burn calories and body fat. It's a 3-day challenge, so children must attempt to perform this video workout everyday for 3 days! If the workout is enjoyable then further performance of the exercises is recommended. Good luck and let's begin the workout! And don't forget to subscribe to the channel if you want to receive new video workouts every Monday! Let's go! 💪🔥

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Often times what I find missing in salads are an adequate amount of protein. Yes they are healthy, full of greens and veggies but lack protein which is the number one essential macronutrient. Use these salads as a guide to get more protein in your salads. Please try these asap! Find my spices and cookbooks at https://www.cookwithjb.com 1:1 Coaching: https://www.truevinefitcoaching.com/ #MuscleChef #MealPrep #FoodVlogger #HealthyFood #Chef #Salad Subscribe, Like & Comment for feedback My other sites 👇🏾 Instagram: @jbailey_justdoit TikTok:@jbailey_justdoit Training App: https://joshbaileyapp.com Website: https://www.truevinefit.com

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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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