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2025-11-18

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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt

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Embarking on a Transformational Journey

Scott Disick, a name synonymous with celebrity culture and reality television, has always been in the limelight, particularly through his association with the Kardashian family. However, beyond the glamour, Disick has found himself on a profound journey of personal transformation that transcends physical appearances. Over the past few years, he has made significant strides in both his body and mind, showcasing an inspiring weight loss journey that resonates with many who seek to improve their health and well-being. This incredible transformation has not only altered his physical stature but has also had a profound impact on his mental health and life perspectives.

Disick’s journey did not begin with a sudden realization but rather a gradual acknowledgment of his lifestyle. Living in the fast lane, marked by extravagant parties, indulgent meals, and a busy social calendar, he reached a point in his life where he recognized the toll it was taking on his health. With increasing media focus on his lifestyle choices and the pressures that come with being a public figure, Scott took it as a wakeup call to reassess his habits. This critical juncture sparked a quest for personal improvement that would not only redefine his body but also reframe his thinking and approach to life.

What makes Scott’s story particularly compelling is that it embodies the struggles many face in pursuit of self-improvement. Despite starting from a place of privilege, his journey reveals deep vulnerabilities, showcasing how anyone can encounter personal battles regardless of their circumstances. From initial setbacks to discovering effective strategies, Disick’s weight loss transformation is not merely about shedding pounds but rather embracing a healthier lifestyle aligned with personal values and goals. This article aims to provide an in-depth look at Scott Disick’s incredible journey, addressing the challenges he faced and the triumphs he achieved along the way.

Understanding the Initial Challenges

At the onset of his weight loss journey, Scott Disick confronted an array of challenges that many can relate to. The pressures of celebrity life come with the constant scrutiny of physical appearances. The intense media spotlight added a layer of complexity to Disick’s journey, as he was often evaluated based on aesthetics rather than well-being. Particularly, the social gatherings filled with high-calorie foods and excessive drinking posed significant obstacles to any efforts he might have made towards healthier choices. This environment made it hard for him to commit to the changes he desperately needed.

Compounding the difficulty was Disick’s emotional relationship with food and lifestyle. For many, food serves not only as nourishment but as a source of comfort during troubling times. Disick found himself in such a scenario, using food and late-night indulgences to cope with personal struggles, particularly following the loss of his parents and various relationship challenges. This cycle of emotional eating further exacerbated his situation, creating a detrimental loop that required enormous strength and determination to break free from.

Moreover, the lack of a structured support system during his initial phase posed another hurdle. While Disick has a strong support network in the Kardashian clan, embarking on a personal health journey often requires an individual to seek support beyond their immediate surroundings. Understanding the need for expert guidance, such as nutritionists and personal trainers, became imperative. This realization at the beginning of his journey laid a critical foundation for the transformative changes he would later embrace.

Adopting a New Lifestyle

Once Scott Disick acknowledged the challenges he faced, he began to implement substantial changes to his lifestyle. One of the primary steps was to adopt a more balanced and nutritious diet. Moving away from high-calorie foods often found at lavish parties and in his former eating habits, Disick began prioritizing whole foods rich in nutrients that fueled his body instead of weighing it down. This shift was not merely about caloric restriction but about making smarter food choices that aligned with his long-term health goals.

A significant component of Scott’s transformation included incorporating regular exercise into his routine. Exercise served as a dual benefit for him; physically, it helped him burn calories and build muscle, while mentally, it became an outlet for stress relief and emotional healing. From weightlifting to cardio workouts, Disick found a variety of activities that not only enhanced his physical appearance but also contributed to mental clarity and emotional stability. This newfound passion for fitness allowed him to break free from the confines of his past lifestyle, gradually building resilience against temptations that had previously derailed him.

Throughout this process, Scott also learned the importance of accountability and surrounding himself with positive influences. By engaging with personal trainers, nutritionists, and wellness coaches, he cultivated a supportive environment that encouraged progress and fostered growth. Such relationships proved vital as they provided him with not only the tools and strategies to stay on track but also the encouragement he needed during low points. Learning to celebrate small victories became essential, reinforcing a positive mindset that propelled him forward in his journey.

The Role of Mindfulness and Mental Health

Equally important to Scott Disick’s weight loss journey was the emphasis on mental health and mindfulness. Recognizing that weight loss is not solely a physical endeavor but also a mental one, Disick sought to address the underlying issues that contributed to his previous habits. Mindfulness became a focal point; practices such as meditation and yoga were incorporated into his regimen, enabling him to cultivate self-awareness and resilience against stress. This holistic approach allowed him to build a stronger relationship with himself, recognizing triggers and patterns that previously led to unhealthy coping mechanisms.

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Scott also pursued therapy as part of his mental health journey. Engaging in conversations about his past traumas, such as the loss of his parents, helped him process emotions he had long suppressed. Through therapy, he gained clarity about the factors contributing to his emotional eating and developed healthier coping strategies to manage stress without resorting to food or substance use. This deeper understanding of his psyche enabled him to confront issues head-on, ultimately leading to healthier decisions in both his personal life and weight management objectives.

As Scott continued to prioritize his mental health, he learned the significance of self-compassion and acceptance. Acknowledging that setbacks are part of the journey helped him to approach challenges with a balanced mindset rather than a punitive one. This shift in perspective allowed him to embrace his body as it changed, fostering a healthy relationship with himself. Ultimately, by intertwining mental and physical wellness, Disick achieved a more comprehensive transformation that radiated authenticity and fulfillment.

The Impact of Transformation on Life and Relationships

Scott Disick’s weight loss journey has undoubtedly reshaped his physical appearance, but the profound effects extend far beyond the surface. As he evolved, so did his relationships. Friends and family witnessed a noticeable change in his attitude and demeanor, leading to deeper connections and improved interactions. This transformation has not only fostered positive growth within himself but has also influenced those around him. Scott’s commitment to health inspired his loved ones to reconsider their lifestyles, creating a ripple effect of wellness within his social circle.

Significantly, his new outlook has played a crucial role in his approach to parenting. As a father, Disick understood the importance of setting a positive example for his children. By demonstrating resilience, commitment, and a healthy lifestyle, he instilled values of wellness and self-care in his family. Engaging in physical activities with his children and promoting balanced eating habits became pivotal, as he understood that these are lessons that would carry into their futures. The shift toward a healthier lifestyle also allowed him to participate more actively in their lives, fostering memories and experiences that are rooted in well-being and joy.

Moreover, Scott’s transformation has manifested in his professional life as well. Through his journey, he developed a newfound sense of confidence and purpose. With this, he has ventured into various business opportunities that align with his wellness brand. His experiences have motivated him to share his story with others facing similar struggles, fostering a sense of community and support through social media platforms. By showcasing his journey openly, Disick has become a beacon of hope for fans and followers, illustrating the possibility of change and self-improvement regardless of one’s starting point.

Reflections on the Journey and Future Aspirations

Scott Disick’s incredible weight loss journey serves as a testament to the power of determination, resilience, and self-discovery. Reflecting on his experiences, he acknowledged that while transformation is a multifaceted process, the commitment to evolving oneself is paramount. The path has been lined with obstacles and struggles, but each challenge has imparted lessons that have shaped him into the person he is today. The journey towards self-improvement is ongoing, and Disick continues to embrace each day as an opportunity to grow and learn.

Looking ahead, Scott envisions maintaining his healthy lifestyle while inspiring others along the way. With the knowledge and experiences gained, he aims to delve deeper into wellness initiatives, perhaps even launching programs that encourage mental and physical health among individuals grappling with similar challenges. His desire to advocate for wellness reflects a commitment not only to his journey but to the larger community that faces the complexities of modern lifestyle pressures.

Ultimately, Scott Disick’s incredible transformation is an embodiment of hope and possibility. His journey illustrates that change is both achievable and worthwhile, providing a roadmap for countless individuals seeking to embark on their own paths of self-improvement. As he continues to evolve, Scott remains a living testament to the belief that a transformation of body and mind can lead to a fuller and more profound existence.

Summary and Common Inquiries

Throughout this exploration of Scott Disick’s remarkable weight loss journey, several key themes emerge that resonate with anyone seeking positive change. First and foremost, the acknowledgment of personal challenges serves as a critical step towards transformation. Recognizing one’s struggles is not a sign of weakness but rather a testament to self-awareness and the desire to improve. Disick’s story exemplifies how confronting these challenges head-on is essential for growth.

It’s also evident that adopting a healthier lifestyle goes beyond mere weight loss; it encompasses the integration of a balanced diet and regular exercise, complemented by mental wellness practices. The correlation between physical health and mental clarity highlights the importance of a holistic approach in achieving long-term success. Disick’s experiences show the value of personal accountability, support systems, and expert guidance in navigating the complexities of personal transformation.

As fans examine Scott’s journey, many often wonder about the sustainable aspects of weight loss and health management. Will he maintain his progress? How does he deal with setbacks? Such inquiries are common as individuals seek to understand how success can be enduring rather than fleeting. For Scott, the answer lies in continuous commitment and a genuine desire to embrace wellness as a lifestyle choice rather than a temporary solution. He remains dedicated to sharing his experiences while encouraging others to embark on their journeys, emphasizing that transformation is not merely a destination but rather an ongoing process.

Another frequently asked question surrounds the role of vulnerability in this journey. Disick’s candid reflections provide insight into how embracing vulnerability can lead to empowerment and self-growth. By openly discussing his struggles, he cultivates authenticity, allowing others to connect with his experiences on a deeper level. This connection serves as encouragement for individuals to share their challenges, fostering a community grounded in support and understanding.

Lastly, a common takeaway from Scott’s narrative is the inspiration his journey ignites in others. His transformation illustrates that self-improvement is possible at any point in life, regardless of circumstances. As many strive for healthier lifestyles, Scott’s dedication serves as a reminder that perseverance, support, and self-compassion play monumental roles in crafting a fulfilling journey of transformation. In sharing his story with the world, he uplifts and motivates countless others to embark on their paths toward health, happiness, and personal fulfillment.

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Weight Watchers and the Ketogenic diet have both gained popularity in recent years for their effectiveness in helping people lose weight and improve their overall health. While these two diets may seem drastically different, they actually share some common ground when it comes to their core principles. Both diets focus on limiting certain foods while encouraging the consumption of others, and both emphasize the importance of portion control and mindful eating. With these similarities in mind, it is possible to blend the philosophies of Weight Watchers and the Keto diet to create a customized eating plan that suits your individual needs and preferences.

Understanding Weight Watchers and the Ketogenic Diet:

Weight Watchers, now known as WW, is a popular weight loss program that uses a point system to help participants make healthier food choices. Foods are assigned a point value based on their nutritional content, and participants are given a daily points target to stay within. The program emphasizes the importance of eating whole, nutrient-dense foods while also allowing for indulgences in moderation. Weight Watchers encourages a balanced approach to eating, focusing on portion control and mindful eating habits.

The Ketogenic diet, or Keto diet, is a high-fat, low-carb eating plan that aims to put the body into a state of ketosis. Ketosis is a metabolic state in which the body burns fat for fuel instead of carbohydrates. By drastically reducing carb intake and increasing fat consumption, the Keto diet can help people lose weight and improve certain health markers. The diet typically includes foods like meat, fish, eggs, nuts, seeds, and healthy fats like avocado and olive oil, while excluding starchy vegetables, grains, and sugary foods.

Blending Weight Watchers and the Ketogenic diet involves combining the key principles of both eating plans to create a sustainable and effective way of eating. By focusing on nutrient-dense foods with a balance of healthy fats, protein, and carbohydrates, you can create a satisfying and nourishing diet that supports weight loss and overall health. This hybrid approach allows for flexibility and customization, making it easier to adhere to the plan long-term and achieve your health and fitness goals.

The Benefits of Blending Weight Watchers and the Keto Diet:

One of the main benefits of blending Weight Watchers and the Keto diet is the potential for improved weight loss results. By combining the portion control and mindful eating principles of Weight Watchers with the metabolic advantages of the Keto diet, you can create a well-rounded eating plan that supports fat loss and overall health. This blend of principles allows for a flexible approach to eating while still encouraging you to make nutritious choices that support your weight loss goals.

Another benefit of blending Weight Watchers and the Keto diet is the potential for improved energy levels and mental clarity. The Keto diet is known for its ability to provide a steady source of energy by utilizing fat stores for fuel. By incorporating the principles of the Keto diet into your Weight Watchers plan, you may experience increased energy levels and improved focus throughout the day. This can help you stay on track with your weight loss goals and lead a more active and fulfilling lifestyle.

Blending Weight Watchers and the Keto diet can also lead to better overall health and wellness. By focusing on nutrient-dense, whole foods and avoiding processed and sugary foods, you can support your immune system, digestion, and heart health. The Ketogenic diet has been shown to improve certain health markers like blood sugar levels and cholesterol, while Weight Watchers promotes a balanced approach to eating that supports overall well-being. By combining these two diets, you can create a balanced and sustainable way of eating that helps you look and feel your best.

Tips for Blending Weight Watchers and the Keto Diet:

When blending Weight Watchers and the Keto diet, it’s important to focus on nutrient-dense, whole foods that align with both eating plans. Choose lean proteins, healthy fats, and fiber-rich carbohydrates to create balanced meals that support your weight loss goals. Incorporate plenty of vegetables, fruits, nuts, seeds, and high-quality proteins like chicken, fish, and tofu into your diet to ensure you are getting a variety of nutrients.

Pay attention to portion sizes and listen to your body’s hunger and fullness cues when blending Weight Watchers and the Keto diet. Both eating plans emphasize the importance of mindful eating and portion control, so be sure to eat slowly, savor your meals, and stop when you are satisfied. By being mindful of your eating habits and honoring your hunger and fullness signals, you can create a sustainable way of eating that supports your weight loss goals and overall health.

Stay hydrated and prioritize self-care when blending Weight Watchers and the Keto diet. Drinking plenty of water throughout the day can help support digestion, curb hunger, and keep you feeling energized and focused. Additionally, incorporating stress-relieving activities like yoga, meditation, or mindful breathing can help you manage stress levels and support your mental and emotional well-being. By taking care of your body and mind, you can create a healthy and balanced lifestyle that supports your weight loss and wellness goals.

Conclusion

Blending the philosophies of Weight Watchers and the Ketogenic diet can offer a unique and effective approach to weight loss and overall health. By combining the principles of portion control, nutrient-dense eating, and mindful eating habits, you can create a customized eating plan that suits your individual needs and preferences. Whether you are looking to lose weight, improve your energy levels, or enhance your overall well-being, blending Weight Watchers and the Keto diet can help you achieve your health and fitness goals in a sustainable and enjoyable way.

FAQs about Weight Watchers and Keto Gummies:

Q: Can I blend Weight Watchers and the Keto diet if I have dietary restrictions or food allergies?
A: Yes, you can customize your eating plan to accommodate your dietary restrictions and food allergies when blending Weight Watchers and the Keto diet. Focus on choosing foods that align with both eating plans and meet your individual needs and preferences. Consult with a healthcare professional or registered dietitian for personalized guidance and support.

Q: How can I stay motivated and on track when blending Weight Watchers and the Keto diet?
A: Stay motivated and on track when blending Weight Watchers and the Keto diet by setting realistic goals, tracking your progress, and celebrating your achievements. Find support from friends, family, or online communities to stay accountable and inspired on your health and wellness journey. Remember to be kind to yourself and stay focused on your reasons for making positive changes to your eating habits.

Q: Are there any potential side effects or risks associated with blending Weight Watchers and the Keto diet?
A: It’s important to listen to your body and make adjustments as needed when blending Weight Watchers and the Keto diet. Some people may experience temporary side effects like fatigue, headaches, or cravings as the body adjusts to a new way of eating. Be mindful of your body’s signals and consult with a healthcare professional if you have any concerns or questions about your health and well-being.

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Q: How can I incorporate Keto gummies into a blended Weight Watchers and Keto diet plan?
A: Keto gummies can be a convenient and delicious way to satisfy your sweet cravings while sticking to your eating plan. Look for Keto gummies that are low in sugar and carbs and made with natural ingredients like gelatin, fruit extracts, and stevia. Enjoy Keto gummies in moderation as a treat or snack to enhance your blended Weight Watchers and Keto diet plan.

Q: Can I follow a blended Weight Watchers and the Keto diet plan long term?
A: Yes, you can follow a blended Weight Watchers and the Keto diet plan long term by making sustainable lifestyle changes and listening to your body’s needs. Focus on creating a balanced and varied eating plan that supports your weight loss and overall health goals. Be flexible and adaptable with your eating habits, and remember to prioritize self-care and mindfulness to maintain a healthy and enjoyable way of eating for the long haul.