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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]
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A new trend of microdosing weight-loss injectables like Ozempic is starting to take hold. While reasons for doing this vary, experts say the practice is not recommended. Global health reporter Katherine Ward explains why. For more info, please go to https://globalnews.ca/video/11166978/microdosing-ozempic-not-recommended-doctors-say/ Subscribe to Global News Channel HERE: http://bit.ly/20fcXDc Like Global News on Facebook HERE: http://bit.ly/255GMJQ Follow Global News on X HERE: http://bit.ly/1Toz8mt Follow Global News on Instagram HERE: https://bit.ly/2QZaZIB #GlobalNews #Ozempic #Health #Microdosing
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What are the best foods to eat on a keto diet? In this video, Dr. Andreas Eenfeldt shares our top tips for choosing keto foods. Find out what to eat, what to drink, and what to avoid — along with the number one keto mistake that might be stalling your weight loss. Read the full guide at https://www.dietdoctor.com/low-carb/keto/foods Subscribe to our channel if you don't want to miss any of our videos: https://www.youtube.com/c/DietDoctorVideo?sub_confirmation=1 About us: DietDoctor.com is the world's number one low-carb site. Follow us for delicious recipes, meal plans and tools to make your low-carb and keto lifestyle simple. But this YouTube channel does not contain all our videos!

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🔥 Ketogene Ernährung leicht gemacht: Meine TOP 15 Keto-Lebensmittel! 🥑🍳 Möchtest du wissen, wie ich 30 kg abgenommen, Muskeln aufgebaut und mich fitter denn je gefühlt habe? 💪 In diesem Video zeige ich dir die Lebensmittel, die mich seit über 11 Monaten ketogen begleiten – einfach, lecker und perfekt für deine Keto-Reise! 🚀 📖 Was du in diesem Video erfährst: ✅ Die besten Proteinquellen: Eier, Bacon, Rinderhack und Käse. ✅ Essenzielle Fettquellen: Kokosöl, Avocado, Olivenöl, Butterschmalz und Schwarzkümmelöl. ✅ Tipps zu Nüssen, Backkakao und ketogenen Desserts. ✨ Meine Highlights im Video: Mein Energie-Boost: Eier & Bacon für einen perfekten Start in den Tag. Warum Avocado & Olivenöl unverzichtbar in der Ketose sind. Mein süßes Keto-Dessert mit nur 9 g Kohlenhydraten – perfekt gegen Heißhunger! 🌟 Warum ketogene Ernährung? Mit der ketogenen Ernährung habe ich nicht nur Fett verloren, sondern auch meine mentale Klarheit und körperliche Energie auf ein neues Level gebracht. In diesem Video zeige ich dir, wie du das Beste aus der Ketose herausholen kannst. 📌 Nützliche Links für deine Keto-Reise: 👉 Mein Olivenöl mit hohem Polyphenolgehalt: https://linktr.ee/kevinfrankgerlach 👉 Meine Anleitung für ketogene Ernährung & Rezepte: https://keto-anleitung.de/ 👉 Tritt meiner WhatsApp-Community bei und erhalte tägliche Rezeptideen: https://keto-anleitung.de/ 💬 Schreib mir in die Kommentare: Was sind deine Lieblingslebensmittel in der ketogenen Ernährung? Hast du eigene Tipps oder Fragen? Ich freue mich auf dein Feedback! 😊 👍 Vergiss nicht: 🔔 Dieses Video zu liken, wenn es dir gefallen hat. 🔔 Meinen Kanal zu abonnieren, um keine neuen Keto-Tipps, Rezepte und Inspirationen zu verpassen! 📅 Bleib dran: Im nächsten Video zeige ich dir noch vieles mehr zur ketogenen Ernährungsweise
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Are There Any Drug Interactions With Berberine? In this informative video, we will discuss the important topic of berberine and its interactions with various medications. Berberine has gained popularity for its potential benefits in managing weight and addressing conditions such as polycystic ovary syndrome. Understanding how berberine might affect your current medications is vital, especially if you are considering it as a supplement for weight management or health improvement. We will cover the medications that may interact with berberine, including cyclosporine and metformin, and explain the potential effects of these interactions. Additionally, we will highlight the importance of consulting with a healthcare provider before starting berberine supplementation, particularly for those already managing health conditions. Monitoring your health after starting any new supplement is essential, and we will provide practical tips on how to do this safely. By prioritizing your health and seeking professional guidance, you can make informed decisions regarding berberine and your overall well-being. Join us for this essential discussion, and don’t forget to subscribe to our channel for more helpful information on weight management and health-related topics. ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@ObesityFightersClub/?sub_confirmation=1 #Berberine #WeightManagement #PolycysticOvarySyndrome #DrugInteractions #HealthSupplements #MedicationSafety #DiabetesManagement #InsulinSensitivity #GutHealth #HealthcareProvider #Obesity #HealthTips #WellnessJourney #Supplements #ChronicConditions #HealthyLiving About Us: Welcome to Obesity Fighters Club! Our channel is dedicated to helping you achieve your weight loss goals and embrace a healthier lifestyle. We cover a variety of topics, including effective weight loss tips, healthy eating habits, and fitness motivation tailored for all levels. Whether you're seeking fat-burning workouts or meal planning strategies for sustainable weight loss, we’ve got you covered.The content provided is for general, informational, and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.
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Open RNY Gastric Bypass post-op Jennifer D. answers the question: "Did you have any complications from weight loss surgery?" 2 years, 8 months post-op Open RNY Gastric Bypass Peak weight was 340 lbs. Weight at interview: 155 lbs. www.obesityhelp.com
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