Achieve Your Weight Loss Goals With Semaglutide In Planotx Wylietx

Last updated on 2025-11-18

2025-11-18

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Psychiatry Grand Rounds April 19, 2024 Glucagon-like peptide-1 (Glp1) receptor (Glp1r) agonists are drugs originally developed to treat type 2 diabetes but that are now also approved to treat obesity by promoting weight loss. This talk describes ongoing research in my lab focused on understanding the molecular mechanisms by which Glp1r agonists promote weight loss. Julio Ayala, PhD Associate Professor, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine https://www.vumc.org/psychiatry/grand-rounds/psychiatryGR_Ayala Objectives: The activity is designed to help the learner: 1. Describe background information about the biology and clinical use of Glucagon-like peptide-1 receptor (Glp1r) agonists. 2. Discuss the importance of pre-clinical investigations on the mechanism of action of Glp1r agonists. 3. Describe pre-clinical research conducted in the Ayala lab focusing on molecular mechanisms mediating the weight loss effect of Glp1r agonists. CME/CE credit for Psychiatry Grand Rounds is only available during the live feed time and for a brief time immediately following. The code for this week's session is displayed at the opening and closing of the meeting

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As obesity rates continue to rise worldwide, researchers are constantly looking for new and effective ways to help individuals lose weight and improve their overall health. One medication that has shown promising results in weight loss is semaglutide, originally developed to treat type 2 diabetes. Recent studies have found that semaglutide can also aid in weight loss in individuals without diabetes, making it a potentially game-changing medication in the fight against obesity.

How Semaglutide Works

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These medications work by mimicking the effects of a hormone called GLP-1, which is released by the gut in response to food intake. GLP-1 helps regulate blood sugar levels, decrease appetite, and slow down digestion, which can lead to feelings of fullness and reduced calorie intake.

In addition to its effects on blood sugar and appetite, semaglutide also appears to have beneficial effects on metabolism. Some studies have shown that semaglutide can increase the body’s energy expenditure, or the number of calories burned at rest, which may contribute to its weight loss effects.

It is also thought that semaglutide may have an impact on food preferences and cravings, leading to healthier food choices and reduced intake of high-calorie, unhealthy foods. By addressing both the physical and psychological aspects of weight loss, semaglutide offers a comprehensive approach to managing obesity.

Potential Benefits of Semaglutide for Weight Loss

One of the main advantages of semaglutide as a weight loss medication is its ability to produce significant and sustained weight loss. Clinical trials have shown that individuals who take semaglutide in combination with lifestyle changes, such as diet and exercise, can achieve greater weight loss compared to those who only make lifestyle modifications.

Another benefit of semaglutide is its potential to improve other health markers associated with obesity, such as blood pressure, cholesterol levels, and blood sugar control. By promoting weight loss, semaglutide may help reduce the risk of developing obesity-related conditions, such as type 2 diabetes, heart disease, and certain types of cancer.

In addition to its weight loss and metabolic benefits, semaglutide has also been shown to have a positive impact on quality of life. Many individuals who take semaglutide report feeling more energetic, motivated, and confident as they progress on their weight loss journey, leading to improved overall well-being.





Potential Side Effects of Semaglutide

Like any medication, semaglutide may cause side effects in some individuals. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication.

In rare cases, more serious side effects of semaglutide may occur, such as pancreatitis (inflammation of the pancreas) or thyroid tumors. It is important for individuals taking semaglutide to be aware of these potential risks and to discuss any concerns with their healthcare provider.

Individuals with a history of pancreatitis, thyroid disease, or multiple endocrine neoplasia syndrome type 2 (a rare genetic disorder) should not take semaglutide. It is important to consult with a healthcare provider before starting semaglutide or any other weight loss medication to determine if it is safe and appropriate for individual health needs.

Conclusion

Semaglutide shows great promise as a weight loss medication for individuals struggling with obesity. Its unique mechanism of action, coupled with its proven efficacy and potential health benefits, make it a valuable tool in the fight against obesity-related diseases. However, like any weight loss medication, it is important to use semaglutide under the guidance of a healthcare provider and in conjunction with healthy lifestyle habits to maximize its effectiveness and minimize potential risks.

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In der heutigen Welt, in der viele Menschen unter Übergewicht und damit verbundenen Gesundheitsproblemen leiden, ist es wichtig, auf eine gesunde Ernährung zu achten. Leckere und gesunde Gerichte zum Abnehmen können dabei helfen, das Gewicht zu reduzieren und gleichzeitig den Körper mit wichtigen Nährstoffen zu versorgen. In diesem Artikel werden wir einige köstliche Rezepte vorstellen, die nicht nur gut schmecken, sondern auch beim Abnehmen unterstützen.

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Linsen sind reich an Proteinen und Ballaststoffen, die lange satt halten und die Verdauung fördern. Für den Salat die Linsen nach Packungsanleitung kochen und mit gewürfeltem Feta, Tomaten, roten Zwiebeln und frischen Kräutern vermischen. Mit einem Dressing aus Zitronensaft, Olivenöl, Senf, Honig, Salz und Pfeffer abschmecken.

Zutaten: 200g grüne Linsen, 100g Feta, 2 Tomaten, 1 rote Zwiebel, frische Kräuter, Zitronensaft, Olivenöl, Senf, Honig, Salz, Pfeffer.

Anleitung: Linsen kochen, mit Feta, Tomaten, Zwiebeln und Kräutern vermischen. Dressing aus Zitronensaft, Olivenöl, Senf, Honig, Salz und Pfeffer zubereiten und über den Salat geben.

Gefüllte Paprika mit Quinoa

Paprika sind reich an Vitamin C und Ballaststoffen, die das Immunsystem stärken und die Verdauung unterstützen. Für die gefüllten Paprika Quinoa kochen und mit gewürfeltem Gemüse wie Zucchini, Möhren, Tomaten und Lauch vermischen. Die Mischung in die Paprika füllen und im Ofen backen, bis sie weich sind.

Zutaten: 4 Paprika, 200g Quinoa, 1 Zucchini, 2 Möhren, 2 Tomaten, 1 Lauch, Gewürze nach Belieben.

Anleitung: Quinoa kochen, mit gewürfeltem Gemüse vermischen. Paprika aushöhlen, mit der Quinoa-Gemüse-Mischung füllen und im Ofen backen.

Gebackener Lachs mit Brokkoli

Lachs ist reich an Omega-3-Fettsäuren, die entzündungshemmend wirken und das Herz-Kreislauf-System unterstützen. Für das Gericht den Lachs mit einer Marinade aus Zitronensaft, Olivenöl, Knoblauch und frischen Kräutern einreiben und im Ofen backen. Dazu gedämpften Brokkoli servieren.

Zutaten: 4 Lachsfilets, Zitronensaft, Olivenöl, Knoblauch, frische Kräuter, Brokkoli.

Anleitung: Lachsfilets mit Marinade einreiben, im Ofen backen. Brokkoli dämpfen und zusammen mit dem Lachs servieren.

Vegetarische Gemüsesuppe

Eine leichte Gemüsesuppe eignet sich hervorragend als gesunde Mahlzeit zum Abnehmen. Für die Suppe verschiedene Gemüsesorten wie Karotten, Sellerie, Lauch, Zucchini und Tomaten in Gemüsebrühe kochen und mit Kräutern und Gewürzen abschmecken. Eine köstliche und nährstoffreiche Option für eine ausgewogene Ernährung.

Zutaten: Gemüse nach Wahl, Gemüsebrühe, frische Kräuter, Gewürze.

Anleitung: Gemüse schneiden und in Gemüsebrühe kochen. Mit Kräutern und Gewürzen verfeinern und heiß servieren.

Zusammenfassung

Leckere und gesunde Gerichte zum Abnehmen können dabei helfen, das Gewicht zu reduzieren und den Körper mit wichtigen Nährstoffen zu versorgen. Zucchini-Nudeln mit Pesto, Linsensalat mit Feta und Tomaten, gefüllte Paprika mit Quinoa, gebackener Lachs mit Brokkoli und vegetarische Gemüsesuppe sind nur einige Beispiele für gesunde und leckere Rezepte, die beim Abnehmen unterstützen. Mit einer ausgewogenen Ernährung und regelmäßiger Bewegung können Sie Ihren Weg zu einem gesünderen Lebensstil finden.

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These are 8 little-known things about belly fat, how it accumulates, and how to get rid of it. Getting a flat stomach can be very straight forward but there are some things that contribute to fat gain that most people aren't aware of. Many people are looking for the best exercises to reduce belly fat but exercises typically don't contribute as much to fat reduction as diet. 🔥 FREE 6 Week Shred: http://bit.ly/2Bv8CL4 📲 FREE Diet/Workout Planner Tool: http://bit.ly/2N41lTX We're told that Belly fat is unhealthy, unattractive, and based solely on eating too many calories. The common perspective is that anyone can lose their gut and replace it with 6-pack abs just by dieting and working out consistently. And while there is a lot of truth to this it's not entirely accurate and there are many things that nobody really talks about when it comes to belly fat whether it's trainers, influencers, or even doctors.  Starting first with genetics which plays a SIGNIFICANT role. Specifically, we can refer to a study from Uppsala University which found that genetic factors significantly influence fat distribution in the body. (1) The research involved nearly 360,000 participants and found that men accumulated more fat around the abdomen while women tend to store more fat on their hips and legs. Using data from the UK Biobank, the researchers identified almost 100 genes that influence the fat distribution, and many of those effects were stronger or exclusively present in one gender over the other. Another well-known factor that influences body fat distribution in men is testosterone. An older study and analysis published in the International Journal of Obesity found that “Recent studies in men have shown that abdominal fat increases with age and decreasing testosterone concentrations” (2) The good news is that, even if you happen to be more predisposed to storing fat around your midsection, you shouldn't use it as an excuse. You still can get a lean midsection. It just might be a bit harder because your body will burn that fat only after it has burned off the fat from the rest of the body. If you are more likely to store fat around your midsection you'll first likely burn the fat from your extremities like your hand's feet and face. Next will be your arms and legs and eventually it should come off your hips and belly. Since your body's preferential fat storage patterns are likely different than someone else's I always say you should compare your results to yourself only by measuring with a tape measurer, a scale, and how you look in the mirror. As long as you are making progress regardless of how small keep moving in that direction and the belly fat will eventually come off. Another myth about belly fat that has been increasingly coming to light is the myth of spot reduction. Even though far fewer people believe in this nowadays there are still countless people in every gym around the world doing crunches right now believing that they can target and spot reduce their belly fat. But especially lately the academic world has made it crystal clear that you can't shed belly fat solely through ab exercises. For example in a study published in The Journal of Strength and Conditioning Research, participants engaged in four hours of ab training per week for six weeks. Yet, despite their hard work, the ab exercises resulted in no significant belly fat loss or overall fat reduction in general. The researchers concluded, “There was no significant effect of abdominal exercises on body weight, body fat percentage. . . abdominal circumference, abdominal skinfold, and suprailiac skinfold measurements.” To put this into simple terms, chasing a toned and trimmed midsection by only performing endless crunches and sit-ups is essentially a complete waste of time. Instead, your primary focus should be on your diet. Make sure that you’re in a calorie deficit, that you're eating real unprocessed foods found around the outside aisles of your grocery store and you should also be getting enough protein while performing resistance training at least 3 to 4 times a week. That’ll help you get rid of belly fat while maintaining muscle mass. Next, you probably don't know that Vitamin D has a direct connection to belly fat. That's right studies have found that individuals with lower levels of vitamin D tend to have higher levels of belly fat and larger waistlines. (5) Vitamin D is produced in the skin upon contact with sunlight and it plays many important roles in the human body which is why its been linked to protection against heart failure, diabetes, and cancer. However, the crazy thing is that Over 40% of the US population is vitamin D deficient, which some authors call "an ignored epidemic." So you're probably thinking Why does vitamin D cause higher levels of belly fat? Well, even though we need more research to say for sure there are a couple possible reasons for this connection. First, vitamin D is involved in the regulation of insulin....

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This is the first video of my weightloss journey. I hope to get many friends and supporters to keep me going through this time. Thanks! Diet starts January 2. Please subscribe and comment!

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Arecor Therapeutics PLC (AIM:AREC) CEO Sarah Howell joined Proactive's Stephen Gunnion with details of a collaboration with TRX Biosciences to develop an oral GLP-1 product for treating type 2 diabetes and obesity. GLP-1s are therapeutic peptides known for improving blood sugar levels and promoting weight loss. The market for GLP-1 products is expected to reach $100 billion by 2030. Currently, GLP-1 treatment options are predominantly injectable, which limits patient compliance and adoption. Arecor aims to develop an oral GLP-1 with enhanced bioavailability, making it a once-daily pill. This development could significantly increase access to effective treatments for these conditions. Howell told Proactive that Arecor is well-positioned for this development due to its successful track record with its Arestat technology platform, which enhances the profiles of existing therapeutics. The collaboration aims to overcome challenges faced by the only available oral GLP-1, such as low bioavailability and the need for dosing on an empty stomach, by leveraging Arecor's technology in conjunction with TRX Biosciences' Lipper core technology. She said the collaboration complements Arecor's existing diabetes portfolio, which includes two leading insulin products and Gluco, a product for severe hypoglycemia in diabetes patients. The focus is on reducing the daily burden of disease management and improving patient outcomes. TRX Biosciences was chosen for their complementary technology and expertise in oral peptide delivery. The initial development phase will last up to 18 months, aiming to demonstrate the feasibility of a stable, orally delivered GLP-1 with improved bioavailability. #ArecorTherapeutics #TRXBiosciences #DiabetesTreatment #ObesityManagement #GLP1 #OralPeptideDelivery #Bioavailability #TherapeuticPeptides #HealthcareInnovation #PharmaceuticalResearch #ProactiveInvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

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Full interview: http://sigmanutrition.com/episode65/ Episode 65: Lyle McDonald is on the show to discuss the metabolic adaptations that take place when dieting, the connection between cortisol and water retention and the role of leptin in dieting and weight regain. In this episode we discuss: Metabolic adaptations to dieting Low calories + lots of cardio = no weight loss??? What’s actually going on The connection between cortisol and water retention The central role of leptin in bodyweight regulation Leptin resistance Effects of lowered calories on leptin Gender differences in hormonal responses to dieting Carbohydrate refeeds: Can they mitigate leptin drops? Which of Lyle’s books should YOU read?

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Unlike trendy crash diets, keto has been around for nearly 100 years and is backed by science for: ✅ Weight loss & fat burning 🔥 ✅ Blood sugar control & insulin regulation 💉 ✅ Brain health & mental clarity 🧠 ✅ Reducing inflammation & improving energy ⚡ Keto isn’t a trend—it’s a sustainable lifestyle with real health benefits! 💪✨ 💬 How has keto improved your life? Drop your experience below! 👇 https://fitlife-lab.com/ #KetoMyths #KetoForLife #NotAFad #ScienceBacked #LowCarbLifestyle

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