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(13 Jun 2007) HEADLINE: Federal health panel rejects weight-loss drug --------------------------------------- CAPTION: A Food and Drug Administration panel unanimously rejected a closely watched weight-loss drug from Sanofi-Aventis SA, on concerns the drug increases the number of psychiatric events like depression and suicidal thinking among users. (June 13) ---------------------------------------- [Notes:ANCHOR VOICE] [Notes:VO --SHOTS OF PANEL] A FEDERAL HEALTH ADVISORY PANEL HAS UNANIMOUSLY REJECTED A NEW WEIGHT-LOSS DRUG AFTER HEARING TESTIMONY THAT THE DRUG CAN CAUSE PSYCHIATRIC PROBLEMS. TESTS FIND IT CAN INCREASE THE RISK OF SUICIDAL THOUGHTS, EVEN AMONG PATIENTS WHO HAVE NO HISTORY OF DEPRESSION. [Notes:VO --SHOTS OF DRUG] THE DRUG IS CALLED RIMONABANT (rih-MOAN-uh-bant) -- AND IT'S MANUFACTURED BY SANOFI-AVENTIS (sih-NO-fee uh-VEHN-tiss). IN STUDIES -- PATIENTS WHO RECEIVED THE TABLET ONCE DAILY REPORTED TWICE AS MANY PSYCHIATRIC SIDE EFFECTS -- INCLUDING DEPRESSION AND ANXIETY --- AS THOSE WHO RECEIVED A SO-CALLED 'SHAM' TREATMENT. [Notes:SOT --] 'i think these psychiatric side effects are prevalent...some of them are quite significant. [Notes:SOT --] 'I have very high concern about the safety data. When you look at the lifetime animal studies, it's clear we need more longterm data in humans" [Notes:VO -- SHOTS OF DRUG] ALTHOUGH THE DRUG IS CURRENTLY MARKETED IN EUROPE, IT'S NOT YET AVAILABLE IN THE U.S. THE PANEL TOOK TWO VOTES -- AND UNANIMOUSLY VOTED AGAINST IT BOTH TIMES -- MAKING IT UNLIKELY THE F-D-A WILL APPROVE IT. BUT THE AGENCY IS SET TO MAKE A FINAL DECISION IN LATE JULY. [Notes:SOT] people who are overweight and obese are desperate, desperate for any measure (cut) word spreads like wildfire.' [Notes:SOT] 'we are going to have massive use of the drug and we just have small group of people for two year study, yet this is presented as a drug that's going to be lifetime. [Notes:VO] THE MANUFACTURER ADMITS THE DRUG IS NOT APPROPRIATE FOR PEOPLE WITH A HISTORY OF DEPRESSION. IT ALSO SAYS DOCTORS SHOULD SCREEN PATIENTS FOR DEPRESSION BEFORE WRITING A PRESCRIPTION. EXPERTS SAY EVEN IF THE F-D-A DOES APPROVE THE DRUG, IT WOULD LIKELY COME WITH STERN WARNINGS -- WHICH IS SOMETHING THE MANUFACTURER EMBRACES Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: https://twitter.com/AP_Archive Facebook: https://www.facebook.com/APArchives Instagram: https://www.instagram.com/APNews/ You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/266938bc4e3a5a170656de2ca93b9571
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Staying hydrated and maintaining electrolyte balance are crucial when using GLP-1 medications for weight loss. In this episode, we explore how these medications impact hydration, why dehydration can slow progress, and how to replenish essential electrolytes. Learn practical tips to stay energized, avoid side effects, and optimize fat loss. Tune in to make hydration a key part of your weight loss success!
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Up 0.8 Lbs and a public apology and a sort-of rant.
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1. “Get shredded in 12 weeks” Sure, it’s possible—if you’re already lean and dialed in. But if you’re starting 20–40 lbs overweight? It’s going to take longer. Fat loss is about the phase you’re ready for, not some made-up timeline. 2. “Eat intuitively and lose weight” If your intuition got you overweight, it’s probably not the best guide. Intuitive eating works after you’ve built structure, awareness, and discipline—not before. 3. “Lose weight and you’ll look small” You might feel “small” at first, but what you’re really seeing is the fat coming off. And that’s step one. Once you’re lean, then you build. You can’t sculpt until you strip the marble. 4. “Whole foods equal weight loss” Whole foods are great for health, energy, and hunger management—but you can still gain fat eating all organic, grass-fed everything. Calories still count. 5. “Eating late makes you fat” Eating too many calories makes you fat. It doesn’t matter if it’s 9am or 9pm. Your body doesn’t care what time it is—it cares how much energy you’re giving it. Follow for more fat loss content.
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Semaglutide is a medication that has been gaining attention for its potential to help with weight loss. As obesity rates continue to rise worldwide, finding effective treatments for weight management has become a priority in healthcare. Semaglutide, originally developed to treat type 2 diabetes, has shown promising results in clinical trials for weight loss in both diabetic and non-diabetic individuals. In this article, we will explore the average weight loss results observed with semaglutide and what the data says about its effectiveness as a weight loss medication.
Understanding Semaglutide and Weight Loss
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by increasing insulin secretion, slowing down gastric emptying, and reducing appetite. These mechanisms can help individuals feel fuller faster, eat less, and ultimately lose weight. In clinical trials, semaglutide has been shown to be more effective for weight loss compared to other medications or placebo.
Several studies have looked at the average weight loss results with semaglutide across different doses and treatment durations. The findings have been consistent in showing significant weight loss in participants who took semaglutide, regardless of their starting weight or medical history. The weight loss results with semaglutide have been encouraging, leading to its approval for use in weight management by regulatory agencies.
One of the key factors that contribute to the effectiveness of semaglutide for weight loss is its ability to target multiple pathways involved in appetite regulation and energy balance. By addressing both the physiological and psychological aspects of eating behavior, semaglutide can help individuals make sustainable lifestyle changes that support long-term weight management.
Comparing Semaglutide to Other Weight Loss Therapies
When compared to other weight loss therapies such as diet and exercise, behavioral therapy, or weight loss surgery, semaglutide has shown to be more effective in producing significant weight loss results. While lifestyle interventions remain a crucial component of weight management, some individuals may benefit from the additional support that medications like semaglutide can provide.
Unlike some weight loss medications that focus solely on suppressing appetite or increasing metabolism, semaglutide targets multiple mechanisms involved in weight regulation. This comprehensive approach makes it a valuable tool for individuals who have struggled to lose weight through traditional methods alone.
Another advantage of semaglutide is its safety profile and tolerability. While all medications have potential side effects, semaglutide has been well-tolerated in clinical trials, with most adverse effects being mild to moderate in severity. This makes it a viable option for individuals looking for a safe and effective treatment for weight loss.
Long-Term Implications of Semaglutide for Weight Management
As more research is conducted on semaglutide and its effects on weight loss, the long-term implications of using this medication for weight management are becoming clearer. Studies have shown that individuals who continue to take semaglutide after the initial treatment period can maintain their weight loss results and even continue to lose weight over time.
By combining semaglutide with lifestyle modifications such as healthy eating and regular physical activity, individuals can create a sustainable approach to weight management. This holistic approach addresses both the physical and behavioral components of obesity, improving the likelihood of long-term success in maintaining a healthy weight.
Overall, the data on average weight loss with semaglutide suggests that this medication has the potential to be a valuable tool in addressing the growing epidemic of obesity and its associated health risks. With further research and real-world experience, semaglutide may emerge as a key player in the field of weight management, offering hope to individuals struggling to achieve and maintain a healthy weight.
In conclusion, the average weight loss results observed with semaglutide in clinical trials have been significant, demonstrating its potential as an effective treatment for weight management. By targeting multiple pathways involved in appetite regulation and energy balance, semaglutide offers a comprehensive approach to weight loss that can support long-term success. Compared to other weight loss therapies, semaglutide has shown to be more effective in producing sustained weight loss results with a favorable safety profile. As more research is conducted on semaglutide and its long-term implications for weight management, this medication may become an essential tool in the fight against obesity and its associated health risks.
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In today’s fast-paced world, many people are constantly looking for quick and easy solutions to achieve their weight loss goals. With the rise of fad diets and trendy supplements flooding the market, it can be overwhelming to sift through the endless options available. EZ weight loss pills claim to offer a simple and convenient way to shed unwanted pounds without the need for strenuous exercise or strict dieting. But do these pills really deliver on their promises, or are they just another empty gimmick?
The Promise of EZ Weight Loss Pills
EZ weight loss pills are marketed as a magic solution to help individuals lose weight quickly and effortlessly. These pills often claim to suppress appetite, boost metabolism, and increase energy levels, making it easier for users to burn fat and shed pounds. With busy lifestyles and demanding schedules, many people are drawn to the idea of a pill that can help them achieve their weight loss goals with minimal effort.
However, it is important to approach these claims with caution and skepticism. While some EZ weight loss pills may contain ingredients that have been scientifically proven to aid in weight loss, many products on the market make exaggerated claims that are not supported by research. It is crucial to do thorough research and consult with a healthcare professional before adding any supplement to your weight loss regimen.
Additionally, the effectiveness of EZ weight loss pills can vary greatly from person to person. Factors such as individual metabolism, diet, and exercise habits can all impact the results that a person sees from taking weight loss pills. It is essential to remember that there is no one-size-fits-all solution to weight loss, and what works for one person may not work for another.
The Risks of Taking EZ Weight Loss Pills
While EZ weight loss pills may seem like a convenient way to jump-start your weight loss journey, they come with potential risks and side effects that should not be overlooked. Many weight loss pills contain stimulants such as caffeine, which can cause jitters, insomnia, and increased heart rate in some individuals. Other ingredients in weight loss pills may have adverse effects on certain medical conditions or interact with medications.
Furthermore, relying solely on weight loss pills to achieve your goals can lead to a cycle of dependency and yo-yo dieting. Sustainable weight loss requires a combination of healthy eating, regular exercise, and behavior change. Simply taking a pill without making lasting lifestyle changes is unlikely to result in long-term success.
It is also important to be wary of the marketing tactics used by some companies selling EZ weight loss pills. Many products make unsubstantiated claims and utilize before-and-after photos that may be misleading or digitally altered. It is crucial to approach weight loss pills with a critical eye and prioritize your health and well-being above all else.
Making Informed Decisions About Weight Loss
When considering using EZ weight loss pills as part of your weight loss journey, it is essential to approach the decision with caution and critical thinking. Research the ingredients in the pills, consult with a healthcare professional, and consider the potential risks and benefits before making a purchase. Keep in mind that sustainable weight loss is a marathon, not a sprint, and there are no quick fixes or shortcuts to achieving lasting results.
Instead of relying on a pill to do the work for you, focus on making small, sustainable changes to your diet and exercise routine that you can maintain over the long term. Choose whole, nutrient-dense foods, prioritize regular physical activity, and seek support from a healthcare provider or a registered dietitian if needed. Remember that health and wellness are about more than just a number on the scale, and true success comes from a holistic approach to caring for your body and mind.
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In this episode of Bulletproof Mindset, we're diving into the signs that show you're losing body fat without losing muscle. If you've ever wondered how to tell if your fat loss journey is on the right track, this one's for you! I share what to look for, plus tips to keep muscle while shedding those extra pounds. Whether you're just starting out or looking to fine-tune your approach, we've got you covered. And if you are interested in the Bulletproof Coaching Starting Strong Programme: https://www.bulletproofcoaching.co.uk/strong-programme Tune in and let's get you feeling great about your progress! You can follow me on Instagram instagram.com/coachcrossar instagram.com/bulletproofmindset__ If you liked todays video, please consider subscribing & liking the video. Dont be shy to leave a comment :)
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