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The upcoming rollout of Mounjaro in the NHS has sparked an important conversation across the country around weight management. There have been significant improvements in our understanding of weight gain, and the factors that make weight loss so difficult, but sadly damaging beliefs, myths and misconceptions remain about this condition. In the coming years, Mounjaro will start to be used as a tool to help with weight management, but this will begin with a very small group of people who are at the highest risk of harm from their condition, which means that many people will only be able to access this treatment several years into the rollout. This means that we need to look at ways of helping people with their weight now. Thankfully, alongside the design of drugs like Mounjaro, there has been some fantastic research looking at deep-level routes that can support weight loss. This video will provide you with an overview of some of this evidence, along with exploring some of the guidance underpinning the rollout of Mounjaro. There’s a lot to be covered, so future videos will delve further into specific aspects of this, but feel free to have a read through the links below if you would like to learn more: NHS Guidance on the use of Mounjaro in the NHS for Weight Loss: https://www.england.nhs.uk/wp-content/uploads/2025/03/PRN01879-interim-commissioning-guidance-implementation-of-the-nice-technology-appraisal-ta1026-and-the-NICE-fu.pdf SURMOUNT-1 Study for Mounjaro in Weight Loss (this is the main trial which led to NICE’s approval of Mounjaro) https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 The effects of Diet & Exercise on GLP-1: https://onlinelibrary.wiley.com/doi/full/10.1002/edm2.68 Summary of GIP: https://www.sciencedirect.com/topics/neuroscience/gastric-inhibitory-polypeptide The unpredictable effects of blending Food: https://www.forksoverknives.com/wellness/are-smoothies-a-nutritional-pitfall-heres-what-the-science-says/ Widespread Myths & Misconceptions about Obesity: https://pmc.ncbi.nlm.nih.gov/articles/PMC4229150/ Careful approaches to exercise in Obesity: https://www.ncbi.nlm.nih.gov/books/NBK539893/ DISCLAIMER This video is for general informational, educational, and entertainment purposes only. It should not be used to self-diagnose and it is not a substitute for a medical examination, assessment, treatment, diagnosis, prescription, or recommendation. It does not create a healthcare professional-patient relationship between Peter Robertson and you. You should not make any changes to your medications or health regimens without first consulting a Doctor or Prescribing Healthcare Professional. If you have any questions please consult with your current primary care provider. Pete’s Prescribing Tips and Mr Peter Robertson are not liable or responsible for any advice, course of treatment, diagnosis, or any other information, services, or product you obtain through this website or video. #prescribing #gp #nurse #paramedic #healthtips #medicine #medicaleducation #pharmacist #medicalstudent #medicalschool #medicalscience #healthcare #nhs #drug #mounjaro #tirzepatide #weightloss #obesity #weightlossjourney #glp1 #gip #fyp

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Doing a Zepbound weight loss journey recap of week 2 before taking my 3rd injection Tirzepatide (Mounjaro) tomorrow. #zepbound #tirzepatide #tirzepatideweightloss #mounjaro #mounjarojourney #mounjaroweightloss #macro #weightloss #weightlossjourney #glp1 #loseweight Hi! Thanks for joining me on my journey to better health ❤️ I will share updates, tips, successes, and failures. I hope to build a community where we can support each other and share advice and motivation! *** I am not a doctor. Anything I say is about my journey or experience. Please speak to your own healthcare provider for medical advice. *** I am trying to post every day at 8 am. for my weight loss journey and every day at 5 pm. for my garden and homestead. Then, I will move to making videos weekly! I have beekeeping classes starting soon and it will make it difficult to post twice a day everyday when that starts ❤️🐝 🍍 MENTIONED IN VIDEO 🍍 https://amzn.to/4aFbi5V Dr. Nina Ellis Hervey Why I Don't Have LOOSE SKIN After 100 Pound Weight Loss WITHOUT Surgery https://youtu.be/T4G_SlkVWSo?si=-sx3GhahZ_j8Gk8_ Dr. Berg How To Prevent Sagging Skin with Losing Weight? https://youtu.be/JpmI3Nnyx6o?si=Hw_bKERYIA0x7Hyv ________________________________________________________________________ 🍍 OTHER RELATED VIDEOS 🍍 HOW I PREPARED THE WEEK BEFORE TAKING ZEPBOUND/TIRZEPATIDE https://youtu.be/tzlJY_ZXOGI?si=F640pY57HJ6bV9YT My First Time Injecting Zepbound! Did it hurt? https://youtu.be/KaWA99TkNdg?si=f6OyDx4N7TaIt92U Morning After Taking First Zepbound Shot! Any Side Effects? https://youtu.be/SlhigwrAKVg?si=BbXEaeKukYGOksgG Easy Way to Get More Water on Tirzepatide | Zepbound | To Help Relieve Symptoms https://youtu.be/W4hpGqDBm28?si=gg3_ES_nQrIk96Q- 24 HOURS AFTER ZEPBOUND SHOT | DID I LOSE ANY WEIGHT? https://youtu.be/GMr3zLTYvdo?si=RlpvCySGHgFiwWlb How to Get Your Protein! For Tirzepatide / Zepbound! https://youtu.be/HLg2XEB-eVY My Second Time Injecting Zepbound! Weight Loss Update! Was it Easier? https://youtu.be/AzUfKXUkNUg How to Get Zepbound Using Weight Watchers Clinic: Timeliness & Experience | GLP-1's | Mounjaro https://youtu.be/YYB2ETpskKE Zepbound Grocery Haul Shopping Aldi | Kroger | TJ Maxx For Tirzepatide Protein! Day in the Life VLOG https://youtu.be/76vHEI0NUKM ZEPBOUND WEEK 2: FOOD NOISE & APPETITE SUPPRESSION | NO CRAVINGS https://youtu.be/tZpChLGiC0U Avoiding Loose Skin w/ Zepbound | Tirzepatide Weight Loss Journey https://youtu.be/b3OhhNDmDTs Zepbound | Tirzepatide Week 2 Recap 2.5 mg Weight Loss Journey https://youtu.be/x-KUCnDuC90 ________________________________________________________________________ 🍍 HELPFUL LINKS 🍍 https://pmc.ncbi.nlm.nih.gov/articles.... https://investor.lilly.com/news-relea... https://pmc.ncbi.nlm.nih.gov/articles... Here is a link to that standard plan that I found - https://www.joinsequence.com/ww-clinic https://www.weightwatchers.com/us/weight-loss-medication ________________________________________________________________________ 🍍 ELI LILLY SAVINGS CARD 🍍 https://zepbound.lilly.com/coverage-s... ________________________________________________________________________ 🍍 ALL SOCIALS 🍍 https://linktr.ee/beewildhomestead ________________________________________________________________________ SHOP LINKS! 🍍 FOLLOW & SHOP MY AMAZON STORE 🍍 https://amzn.to/4grY5Pa _______________________________________________________________________ DISCLAIMER: Some links are affiliate links, meaning I earn a small commission from your purchase which helps me and my channel out and I definitely appreciate it and you! The price is no different for you :) FTC Disclaimer Required for all Influencers: I am a content creator and an Amazon Influencer. I am also a partner or affiliate with multiple brands. I partner with brands to gain discounts, samples, and provide giveaways for my audience. Some of the links posted throughout my sites I may earn commission from by you making purchases or utilizing the codes for a discount for yourself (This does not increase the price for you). Thank you for doing so, this really helps my channel and to provide quality content for you!

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Drs Piña and Kosiborod discuss semaglutide in obesity-related HF with and without diabetes. Both STEP HFpEF trials show similar HF benefits despite less weight loss in patients with diabetes. https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt -- TRANSCRIPT -- Ileana L. Piña, MD, MPH: Hello, and welcome to my blog. Today, I'm at the American College of Cardiology in Atlanta. I want to introduce and welcome Dr Kosiborod: from the Mid America Heart Institute, who has presented a very impactful paper, STEP HFpEF DM, that is in The New England Journal of Medicine right now. This is about semaglutide. A lot of patients ask me to give them that pill that makes them lose weight. I see primarily patients with heart failure (HF). So, Mikhail, congratulations on your presentation. Give us a little synopsis of what the trial is about. The STEP HFpEF Program Mikhail N. Kosiborod, MD: First of all, it is always a pleasure to be with you. Maybe a quick word about the STEP HFpEF program that included two trials: The first is STEP HFpEF, which was a trial of patients with obesity-related HF with preserved ejection fraction (HFpEF) who did not have diabetes, which we presented and published at European Society of Cardiology in August last year. The second installment of the program is the STEP HFpEF diabetes trial, which is essentially the same population of patients except they also have type 2 diabetes. I guess your question would be why we did two trials instead of just doing one trial that included patients, both with and without diabetes. I'll come back to that shortly. The crux of the hypothesis behind the program is that we all know the prevalence of HFpEF has increased dramatically in the past couple of decades. When I was a fellow in training, it was rare for me to see a patient with HF who had preserved EF. A majority of patients had HF with reduced EF. Now, the majority of people we see have HFpEF: Why did that happen? There are a lot of different reasons for the dramatic change in epidemiology. But certainly, one of them, at least in our opinion, is that the obesity epidemic has a lot to do with it. In fact, if you look at the population of patients with HFpEF in the United States, 80% of them are living with overweight or obesity. The hypothesis behind the program was that obesity is not just a comorbidity. It doesn't just happen to coexist by accident in this patient population, it may in fact be causing their HF. It may be a critical factor in the development and progression of HFpEF. In order to test our hypotheses, patients were randomly assigned to semaglutide, with the target dose of 2.4 mg once a week or matching placebo and treated for 52 weeks, or 1 year. The reason we did two separate trials is because part of that hypothesis was that if obesity is in fact the cause of HF, then certainly, weight loss would be probably not the only factor but "an important factor in the potential benefits of semaglutide in this patient population, provided that semaglutide is beneficial which of course we ultimately demonstrated. But what we knew from weight-loss trials — not HF trials but weight-loss trials of medications like semaglutide and also other anti-obesity medications like tirzepatide and others — is that people with diabetes tend to lose a lot less weight. With these medications, there's about a 40% less weight loss in people with type 2 diabetes. Lots of theoretical reasons why that could be the case. Nobody really knows for sure. We knew from the beginning that the weight loss likely was going to be different. Then, of course, there are other things that happen in people with diabetes: They have more severe HFpEF phenotype, and people with more severe disease sometimes don't respond to treatment the same way as those with less severe disease. Finally, we knew when we started the trial, which was back around 2019, 2020, that people with diabetes would be more likely to be treated with sodium-glucose cotransporter 2 (SGLT2) inhibitors. At the time, we didn't have the data for SLT2 inhibitors in HFpEF, but we knew that were going to be tested. There was, of course, an expectation that they may well be beneficial. For all of these reasons, we said, "You know what, the treatment effects may well be different between the patient population, but let's study them separately." Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt

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